1997, Number 2
Vet Mex 1997; 28 (2)
Candanosa de ME, Estrada PS, Trigo TF, Velázquez EA, Gracia MI, Reynaga OJ
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ABSTRACTTransfer Factor (TF) is a leucocyte dializable extract that has been therapeutically used in human against chronic and neoplasic diseases, and in most of these with positive results. The evaluation of the present study refers to the effect of bovine specific and inespecific TF on the development of melanoma B16, in singenic mice using 100 cases of C57BL/6J specimen. These cases were divided in 5 groups: 1 group as the control, 2 as the prophylactic ones and 2 as the therapeutic ones. B16 melanoma was implanted in every case. In the control group the TF was not applied. The second group (prophylactic) and the fifth one (therapeutic) were injected with specific TF. The third group (prophylactic) and the fourth one (therapeutic) were exposed to inespecific TF. Weight gain and increase of life span (ILS) were evaluated in each group. Results obtained regarding ILS and weight gain show no significant differences (P › 0.05) between the 5 groups. It is concluded that murine B16 melanoma bovine specific and inespecific TF did not show antineoplasic eficiency.