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2008, Number S1

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Cir Gen 2008; 30 (S1)

Gastrointestinal stromal tumors. Current concepts in pathology

Alvarado-Cabrero I, Quiroga GG

Language: Spanish
References: 23
Page: 11-16
PDF size: 123.84 Kb.


ABSTRACT

Gastrointestinal stromal tumours (GIST) are the most common mesenchymal neoplasms in these sites and originate from the interstitial cells of Cajal. In general, they are well circumscribed and friable tumours in the macroscopic examination; their diameter dimensions vary from ‹ 1 cm up to 35 cm. The histologic examination can distinguish two growth patterns: fusiform and epithelioid cells. The differential diagnosis comprises, mainly, smooth-muscle tumors (leiomyomas, leiomyosarcomas), neurogenic neoplasms, and fibromatosis.
A basic immunohistochemical panel to evaluate these tumours must include markers such as CD117, CD34, smooth-muscle actine, and protein S100. Ninety five per cent of GIST is positive to CD117, and 30-40% to CD34. The biological behavior of these neoplasms is assessed considering their size, mitosis number, and localization; the gastric neoplasms have a better prognosis.


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