2003, Number 3
Rev Mex Anest 2003; 26 (3)
Bupernofina en el Periodo Postoperatorio Vía Peridural y Sublingual: Analgesia y efectos Colaterales
Zaldivar RVM, Ríos BAV
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ABSTRACTThis study was assessed to evaluate analgesic effect of buprenorphine 150 mcg using two differents routes after abdominal cholecystectomy or hysterectomy. Material and methods: Forty patients underwent colecistectomy and abdominal hysterectomy were included and randomized divided into two groups: group (P) buprenorphine 150 mcg in epidural space (n = 20) and group (S) 150 mcg sublingual (n = 20). Analgesic effect using VAS, sedation using Ramsey scale, hemodynamic effects (BP, CR, RR), side effects (i.e.: nausea, vomiting, dizziness, itching, respiratory depression, sleepiness, stupor) were recorded. Results: Buprenorphine 150 mcg administrated by epidural space shown better analgesia effect than sublingual via with a significance difference for VAS at 15, 30 and 60 minutes. No statistically significance in BP and SO2 were observed in both groups; however, we observed side effects (nausea and vomiting) in five patients in the group P. None of the patients needed respiratory support. Conclusions: The postoperative pain was better controlled with buprenorphine using epidural space but we recommend antiemetic therapy prior buprenorphine been used. Although none of the patients had side effects with life-treatment we recommend close observation at least the first two hours after the drug was administered.