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Revista Mexicana de Oftalmología

Anales de la Sociedad Mexicana de Oftalmología y Archivos de la Asociación Para Evitar la Ceguera en México
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2008, Number 4

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Rev Mex Oftalmol 2008; 82 (4)

Enfermedad de Mikulicz como parte del síndrome de Sjögren. Reporte de un caso

Hernández-Da Mota SE, Cornejo-Ballesteros RH
Full text How to cite this article

Language: Spanish
References: 11
Page: 256-259
PDF size: 93.99 Kb.


Key words:

Sjögren syndrome, Mikulicz disease, salivary gland hypertrophy.

ABSTRACT

Introduction: Mikulicz disease is a benign disorder characterized by the presence of salivary and lachrymal gland hypertrophy. Causes of this condition include multiple diseases like Sjögren syndrome, although this is considered an uncommon association.
Case report: A 29-year-old male patient complained of enlargement of his superior eyelids and submandibular area for a 2-year period. Initially, diagnosis was of lymphoma-like disease, which was excluded based upon a biopsy specimen that showed a benign lymphoproliferative lesion that is present in Mikulicz disease. Keratitis sicca was documented in the patient but there was no clinical evidence of xerostomia.
Discussion: Although association between Mikulicz disease and Sjögren syndrome is unusual and controversial, it should be considered as a differential diagnosis in all infiltrative lesions that involve salivary and lachrymal glands.


REFERENCES

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  2. Rybakova MG. Autoimmune diseases of the salivary glands. Arkh Patol 1979; 41(11): 85-90.

  3. Kelly DR, Spiegel JC, Maves M. Benign lymphoepithelial lesions of the salivary glands. Arch Otolaryngol 1975; 101(1):71-5.

  4. Piper HF. 100 years of the Mikulicz syndrome. Gesnerus. 1990; 47(1): 83-94.

  5. Leban SG, Stratigos GT. Benign lymphoepithelial sialoadenopathies. The Mikulicz/Sjögren controversy. Oral Surg Oral Med Oral Pathol 1974; 38(5):735-48.

  6. Lee S, Tsirbas A, McCann JD, Goldberg RA. Mikulicz’s disease: a new perspective and literature review. Eur J Ophthalmol 2006; 16(2):199-203.

  7. Yamamoto M, Suzuki C, Naishiro Y, Takahashi H, Shinomura Y, Imai K. The significance of disease-independence in Mikulicz’s disease-revival interests in Mikulicz’s disease. Nihon Rinsho Meneki Gakkai Kaishi 2006; 29(1):1-7.

  8. Tsubota K, Fujita H, Tsuzaka K, Takeuchi T. Mikulicz’s disease and Sjögren’s syndrome. Invest Ophthalmol Vis Sci 2000; 41(7):1666-73.

  9. Ili S, Arsi L, Milosavljevi I, Strbac M, Tomasevi G. Diagnosis of the Mikulicz-Sjögren syndrome using biopsy of the minor salivary glands. Vojnosanit Pregl 2002; 59(6):615-20.

  10. Yamazaki M, Ohmori K, Takinami S, Iizuka T, Fukuda H. Sialography (the fourth report)-Sjögren syndrome and Mikulicz disease. Rinsho Hoshasen 1984; 29(1):79-84.

  11. Calguneri M, Kisacik B. Mikulicz’s syndrome: old disease and new view. J Rheumatol 2007; 34(9):1941.




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Rev Mex Oftalmol. 2008;82