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2008, Number 2

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Rev Med Hosp Gen Mex 2008; 71 (2)

Primary Lymphoma of the thyroid Gland. Histopathological review of three cases

Romero GMB, Macías DDMJ, Hernández GMM, Durán PMA, Williams JD, Alcántara VA
Full text How to cite this article

Language: Spanish
References: 18
Page: 88-93
PDF size: 566.94 Kb.


Key words:

Lymphoma, thyroid gland, thyroiditis, Hashimoto.

ABSTRACT

Primary lymphomas of the thyroid gland constitutes less than 5% of all thyroid neoplasms and up to 80% are associated to Hashimoto´s and to lymphocytic thyroiditis. The most frequent histological types are: diffuse large B cell lymphoma, MALT type marginal zone B-cell lymphoma and unfrequent are follicular lymphoma, plasmacytoma and peripheral T/NK lymphoma. It is a descriptive study of three cases (1.3%). The patients were female of 56, 58 and 70 years of age, presented increased volume of the anterior neck region, asfixia and hoarseness. Two cases were diagnosed as diffuse large B-cell lymphoma and the other as MALT type marginal zone B-cell lymphoma associated to Hashimoto´s thyroiditis. All three non -Hodgkin´s lymphomas presented positivity to B cell markers (CD 20 and CD 79a ), two were positive to bcl-2 and one to bcl-6. We stand out the morphological characteristics of the two types of the thyroid primary lymphomas and his association with Hashimoto´s and lymphocytic thyroiditis and discuss the differential diagnosis.


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Rev Med Hosp Gen Mex. 2008;71