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Instituto Nacional de Salud Pública

2008, Number 5

salud publica mex 2008; 50 (5)

Prevalence of neutralizing antibodies to dengue virus serotypes in university students from Tabasco, Mexico.

Sánchez-Burgos GG, López-Alvarado MA, Castañeda-Desales D, Ruiz-Gómez J, Ramos-Castañeda J

Language: Spanish
References: 12
Page: 362-366
PDF size: 154.44 Kb.


ABSTRACT

Objective. Determine the seroprevalence of neutralizing antibodies to dengue virus in students from the state university of Tabasco, Mexico. Material and Methods. A transversal study was conducted of serum collected from students between September and November, 2005. The sera were screened for anti-dengue IgG and those that had evidence of dengue antibodies were analyzed by a plaque reduction neutralization test. Results. Prevalence of anti-dengue IgG was 9.1%. The frequency of neutralizing antibodies was 100% for DENV-2, 68% for DENV-4, 20% for DENV-1, and 4 % for DENV-3. Conclusions. We found that in this population, DENV-2 circulates more than DENV-3 despite the fact that DENV-3 is more frequently isolated. Unexpectedly, neutralizing antibodies against DENV-4 were frequently found even though this serotype is almost extinct; thus, it is probable that cross-immunity could suppress DEN-4 transmission, as has been suggested.


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