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Organo Oficial de la Sociedad Mexicana de Urología
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2006, Number 3

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Rev Mex Urol 2006; 66 (3)

Infección intrauretral por virus del papiloma humano. Informe de un caso tratado con imiquimod y revisión de la bibliografía

Maldonado ÁM, Castellanos LJ, Cano EFM, Enríquez LJ
Full text How to cite this article

Language: Spanish
References: 7
Page: 135-138
PDF size: 249.78 Kb.


Key words:

Intraurethral papilIomavirus, human papillomavirus, condyloma acuminatum, genital warts, Imiquimod.

ABSTRACT

Genital warts are one of the most common sexually transmitted infections and are attributed to the epidermotropic human papillomavirus (HPV). Over 100 types of HPV have been isolated and completely sequenced thus far.
Intraurethral HPV constitutes a therapeutic challenge to urologists and very diverse treatment recommendations exist in the literature on HPV lesions of urethra. There are no treatment guidelines from the specialists’ societies. The clinical effect of Imiquimod stems from cytokine-induced activation on the immune system. Topical application of Imiquimod increases the production of cytokines, including the principal cytokine for antiviral activity, interferon alpha. We present an 18-year-old man with intraurethral condyloma, who has been previously treated with no success in eradicating the warts. We decided to use Imiquimod showing excellent results and to the date, recurrence of the condylomata was not observed macroscopically.


REFERENCES

  1. Dupin N. Genital Warts. Clin Dermatol. Nov-Dec 2004; 22(6):481-6.

  2. Brown TI, Yen-Moore A. Tyring SK. Revisión de las enfermedades de transmisión sexual (11). J Am Acad Dermatol. Abr 2000;2(2):78-94.

  3. Schneed P, Munich P, Ziller F. Urethral condyloma: A therapeutic challenge. Hautarzt. May 2001; 52(5):411-7.

  4. Tyring SK, Conant M, Mprini M, Van Der Meijden W, Washenik K. Imiquimod: an international update on therapeutic uses in dermatology. Int I Dermatol. Nov 2002;41(11):810-6.

  5. Xiao MZ, Gou M, He ZM. Diagnosis and treatment of urethral condyloma acuminatum in male patients. Zhonghua Nan Ke Xue. 2002;8(2):1124.

  6. Wang XL, Wang WH, Wang HS, Xu SZ, Liao Kh, Hillemanns P. Topical 5-aminolevulinic acid-photodynamic therapy for the treatment of urethral condylomata acuminata. Br J Dermatol. Oct 2004; 15(4):880-5.

  7. Schneede P, Munch P, Wagner S, Meyer T, Stuckfleth E, Hufstetter A. Fluorescence urethroscopy following instillation of 5-aminolevulinic acid: a new procedure for detecting clinical and sub clinical HPV lesions of the urethra. J Eur Acad Dermatol Vener. Mar 2000;15(2):121-5.




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Rev Mex Urol. 2006;66