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Revista Mexicana de Oftalmología

Anales de la Sociedad Mexicana de Oftalmología y Archivos de la Asociación Para Evitar la Ceguera en México
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2009, Number 1

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Rev Mex Oftalmol 2009; 83 (1)

Susceptibilidad a netilmicina en 400 cepas bacterianas aisladas de infecciones oculares

Vanzzini RV, Alcantara-Castro M, Flores V
Full text How to cite this article

Language: Spanish
References: 8
Page: 1-5
PDF size: 121.02 Kb.


Key words:

Aminoglucoside, quinolones, susceptibility.

ABSTRACT

Objective: To know the in vitro susceptibility to netilmicin, gentamicin, tobramycin, amikacin, ciprofloxacin, ofloxacin, moxifloxacin and gatifloxacin in 400 strains isolated from ocular infections in a statistical comparative study.
Material and methods: In a retrospective, comparative and lineal study we made susceptibility test by Kirby and Bauer diffusion technique to 400 Gram positive and Gram negative ocular bacterial isolates, the ocular sources were 171 bacterial keratitis, 148 conjunctivitis, 27 endophthalmitis, and 54 other ocular infections.
Results: The bacterial isolates were 254 Gram positive and 146 Gram negative bacterial strains, 81 Staphylococcus epidermidis, 76 Staphylococcus aureus, 57 Streptococcus , 25 Bacillus, 16 Corynebacterium and Actinomyces, 58 Enterobacteriaceae, 50 Pseudomonas, 17 Haemophilus influenzae and 5 Neisseria. Statistic study by logistic regret ion method was applied.
Conclusions: The susceptibility to netilmicin of Staphylococcus coagulase negative was higher than gatifloxacin and moxifloxacin, equal to gatifloxacin for Gram negative and positive bacteria and better than tobramycin in both mayor bacterial group studied.


REFERENCES

  1. Gilbert DN. Aminoglucósidos. En: Mandel GL, Bennett JE, Dolin R. Enfermedades infecciosas. Principios y práctica. Ed Panamericana, Buenos Aires 1997; 309-340.

  2. Jorgensen JH, Turnidge JD, Washington JA. Antibacterial susceptibility test: Dilution and Disk diffusion methods. En: Murray PR, Jo Baron E, Pfaller MA, Tenover FC, Yolken RH. Manual of Clinical Microbiology. ASM Press, Washington D. C. 7ª. Ed. 1999; 1526-1543.

  3. Papparella AM, De Girolamo N. Piroli C. Use of Netilmicine eye drops in ocular infections in children. Boletino di Oculistica 1994; 75(5):1-4.

  4. Papa V, Aragona P, Scuderi AC, Blanco AR, Zola P, Di Bella A, Santocono M, Milazzo G. Treatment of acute bacterial conjunctivitis with topical Netilmicin. Cornea. 2002; 21(1)43-47.

  5. Milazzo G, Papa V, Carstocea B, Chercota G, Rodica P Gafencu O, Santocono M. Topical Netilmicine compared with tobramycyn in the treatment of external ocular infections. Inter J Clin Pharma Therap 1999; 37(5): 243-248.

  6. Pappa V, Leonardo A, Getuli C, Pacelli V, Russo P, Milazzo G. Effect of Ofloxacin and Netilmicine on human corneal and conjunctival cell in vitro. J Ophthalmol Pharmacol Ther 2003: 19(6); 535-545.

  7. Scuderi AC, de Lazzari A, Miano F, Zola P. Residence time of Netilmicin in tears. Cornea 2002; 21(1): 48-50.

  8. Bonfiglio G, Scuderi AC, Russo G. Netilmicin: In vitro activity, time-kill evaluation and post-antibiotic effect on microorganism isolated from ocular infections. Chemotherapy 2007; 47: 117-122.




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Rev Mex Oftalmol. 2009;83