Capelini-Rodríguez F, Durazo-Quiroz F, Pantoja-Ponce I, Razo-Martínez M

Language: Spanish
References: 11
Page: 113-116
PDF size: 98.94 Kb.

ABSTRACT

Background: The glomerular filtration rate (GFR) has traditionally been considered as the best indicator of kidney function and damage; however, it is not easy to measure in the daily clinical practice. This paper reports an evaluation and comparison of the Modification of Diet in Renal Disease (MDRD) equation, recommended by the National Kidney Disease Education Program (NKDEP) to measure glomerular filtration in the adult population versus the results obtained from the measurement of the 24-hour urinary creatinine clearance. The objective is to show that the MDRD equation to estimate GFR, which uses only the serum creatinine, age and gender variables can be used in the Mexican adult population instead of the 24-hour urinary creatinine clearance. Material and methods: In a group of 237 patients over 18 years of age, of both genders, we compared the GFR results using creatinine clearance and the MDRD equation. Serum and urinary creatinine quantification was done using Jaffe’s method calibrated with isotope-dilution mass spectrometry (IDMS), which has been accepted internationally and is recommended by the NKDEP as the standardization method for creatinine tests. Results: Showed a significant correlation between the MDRD equation and creatinine clearance, with p ‹ 0.001 and R = 0.871 (correlation coefficient), intercept = 0.654 and slope = 0.799. The total percent concordance was 93.52%. Conclusions: Using the MDRD equation to measure GFR in the Mexican adult population is a practical, economic and reliable procedure to report the status of kidney function. The study shows that it is comparable to the results obtained using the traditional 24-hour urinary creatinine clearance method.

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