De Peña OJ, Ramos-Garibay A, Villanueva RTI

Language: Spanish
References: 10
Page: 57-60
PDF size: 140.07 Kb.

ABSTRACT

Pemphigus is a group of autoimmune blistering diseases of the skin and mucous membranes that is characterized by histologically, intraepidermal blisters due to the loss of cell-cell adhesion of keratinocytes; and immunopathologically by the finding of in vivo bound and circulating IgG autoantibodies directed against the cell surface of keratinocytes. Pemphigus can be divided into three major forms: pemphigus vulgaris, with deep blisters in the epidermis and in some cases also in mucous membranes; pemphigus foliaceus with superficial blisters only in the epidermis; and paraneoplastic pemphigus. Pemphigus vegetans is a variant of pemphigus vulgaris; pemphigus erythematosus and fogo selvagem represent the localized and endemic forms of pemphigus foliaceus, respectively. Pemphigus erythematosus, also known as Senear-Usher syndrome is the most frequent form after pemphigus vulgaris. The clinical features include erythematosus and scaly plaques, well defined, with a seborrheic distribution. Most of the patients have been reported between 15 through 84 years of age. Main differential diagnosis include erythematosus lupus and seborrheic dermatitis. In the localized or initial forms, the diagnosis may be hard if the physician has no experience in this cases.

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