Ruiz VRE, Delgado CMM, Ramírez PA, Ojeda VJF

Language: Spanish
References: 7
Page: 80-83
PDF size: 43.98 Kb.

ABSTRACT

We have studied the potency and recovery characteristics of rocuronium during 1.3 MAC of desflurane and sevoflurane anaesthesia in 60 patients divided in groups of 30 subjects each using Train of Four monitoring. In this experimental study the recovery index was determined during anaesthesia with desflurane and sevoflurane. Mann-Whitney test was used, as it results adequate to perform statistical analyses of physical characteristics and pharmacokinetic data. Following equi-effective dosing the 25 T recovery index was 18.23 ± 2.5 and 30.3 ± 4.6 minutes during desflurane and sevoflurane anaesthesia respectively. The 75% index recovery was 33.4 ± 4.6 and 46.1 ± 5.9 minutes under desflurane and sevoflurane anaesthesia respectively. Interaction of rocuronium and volatile anesthetic sevoflurane resulted in increased intensity of neuromuscular block compared with desflurane anesthetic. Significant differences on duration or recovery time and characteristics from the block between desflurane and sevoflurane anaesthesia were determined.

REFERENCES

1. Rupp SM, Miller RD, Gencarelli PJ. Vecuronium induced neuromuscular blockade during enflurane, isoflurane and halothane anesthesia in humans. Anesthesiology 1984; 60: 102-105.

2. Shanks CA, Fragen RJ, Ling D. Continuous intravenous infusion of rocuronium in patients receiving balanced, enflurane, or isoflurane anesthesia. Anesthesiology 1993; 78: 649-651

3. Wulf H, Kahl M, Ledowski T. Augmentation of the neuromuscular blocking effects of cisatracurium during desflurane, sevoflurane, isoflurane or total i.v. anaesthesia. Br J Anaesthesiol 1998; 80: 308-312.

4. Wulf H, Ledowski T, Linstedt U, Proppe D, Sitzlack D. Neuromuscular blocking effects of rocuronium during desflurane, isoflurane, and sevoflurane anaesthesia. Can J Anaesthesiol 1998; 45: 526-532.

5. Agoston S. Interactions of volatile anaesthetics with rocuronium bromide in perspective. Eur J Anaesthesiol 1994; 11 (suppl 9) 107-111.

6. Saitoh Y, Toyouka H, Amaha K. Recoveries of postetanic twitch and train of four responses after administration of vecuronium with different inhalation anaesthetics and neurolepanaesthesia. Br J Anaesthesiol 1993; 70: 402-404.

7. Bock M, Klippel K, Nitsche B. Rocuronium potency and recovery characteristics during steady-state desflurane, sevoflurane, isoflurane and propofol anaesthesia. Br J Anaesthesiol 2000; 84 (1): 43-47.