2009, Number 4
Ortho-tips 2009; 5 (4)
Factores de crecimiento derivados de plaquetas en el trasplante de menisco: trabajo experimental en borregos
Berumen NE, Morales TC, Paz M, Campbell O, Leal BI
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ABSTRACTIntroduction: A comparative study was carried out in Peliguey rams knees to determine the effects of Autologous Growth Factors (AGF) in meniscal transplantation surgery. Material and methods: Eight rams were meniscectomized, four of them had a meniscus transplantation with addition of AGF, the other four just had the transplantation without the AGF and were keepet as control group. All of them had a check up at two and four months after the meniscus transplant. All the meniscus size were messured and an histological analysis was done in order to determine possible cell migration and new blood vessels growing. Results: In Group 1 an increase of the inflammatory reaction in the joint between the capsule and the meniscus was noticed, there was not a cellular restocking inward the allograft. Instead the Group 2 (AGF) was found with a lower inflammatory reaction, a cellular restocking inwards the allograft and growing of new blood vessels close to its edge were observed. A minor shrinkage of the transplanted meniscus was detected in this group compared with the meniscus size of the control group. Discussion: For first time AGF was applied to a meniscus transplantation and a significant difference was observed between the control and those in which AGF were applied. Conclusions: The AGF application in meniscus transplantation is a tool to improve the integration of the implant.