1994, Number 2
Use of terms describing the characteristics of rodents and rabbits in research published in Mexico from 1980 to 1989
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ABSTRACTA bibliographical study, concerning characteristics of laboratory rodents and rabbits used for experimental research in Mexico from 1980 to 1989, was performed. Biological and environmental data was taken from the Material and Method section of articles included in acknowledged Mexican biomedical science journals. Obtained data included: Species and number of animals, strain, biological characteristics (sex, age, weight and genotype), microbiological status, environmental conditions and conditioning period. The mostfrequent species were rat (57.74%), strain Wistar (83%), and mice (15.49%), strain BALB/C (70%). Nevertheless, only 50% of the consulted articles included strain data. Regarding age and weight data there was a tendency to use young adult animals, however, this information was mentioned in only 24% of the articles. With regard to the microbiological status and the environmental conditions of the animals in which the experiments were performed, less than 16% of the reports included these aspects. Conventional animals were mainly used; however, some authors tend to describe the microbiological status of the animal, rather than the environmental conditions in which animals were reared and where the research was performed. The absence of not very accurate and systematic information, reduces the possibilities of reproduction of the experiments and therefore, results. This problem limits the impact of studies at international level. Journal committees should require authors to mention information such as: Species and number of animals, strain, biological characteristics (sex, age, weight and genotype), microbiological status, environmental conditions and conditioning period, systematically.
Anonymous: Guidelines for describing diets for experimental animals. J. Nutr., 114: 15-16 (1984).
Bankowski, J. and Howard-Jones, N.: Biomedical Research Involving Animals: Proposed International Guiding Principles. Council for lnternational Organizations of Medical Sciences, Geneve, Switzerland, 1984.
Bleby, J.: The selection and supply of laboratory animals. In: The UFAW Handbook on the Care and Management of Laboratory Animals. 6th ed. Edited by: Pool, T.B., 8-17. Longman Scientific and Technical, London, 1987.
Committee on Standards for Nutritional Studies: Report of the American Institute of Nutrition ad hoc Committee on Standards for Nutritional Studies. J. Nutr., 107: 1340-1348 (1977).
Committee on the Use of Laboratory Animals in Biomedical and Behavioral Research: Use of Laboratory Animals in Biomedical and Behavioral Research. National Academy Press, Washington, D.C., 1988.
Festing, M.F.W.: Survey of the Number and Types of Laboratory Animals Used in the United Kingdom 1972. Manual Series No. 3. Medical Research Council Laboratory Animal Centre, Carshalton, Surrey, United Kingdom, 1974.
Festing, M.F.W.: Inbred Strain in Biomedical Research. Macmillan, London, 1979.
Festing, M.F.W.: The defined animal and the reduction of animal use. In: Animals in Research: New Pespectives in Animal Experimentation. Edited by: Sperlinger, D., 25-32. Whiley, Chichester, United Kingdom, 1981.
Fox, G.J., Cohen, I.B. and Loew, M.F.: Laboratory Animal Medicine. Academic Press, Orlando, Florida, 1984.
Gärtner, K.: Zur Akklimatisation von Laboratoriumsratten nach Ortawechsel. Res. exp. Med., 158: 180-193 (1972).
Kalter, S.S. and Hennessen, W.: The standardization of animals to improve biomedical research, production and control. Symposium of the International Association of Biological Standardization. London. 1979. 1-5. Karger, London (1979).
Lane-Petter, W.: Survey of Laboratory Animals Produced and Used in Great Britain during 1956. Medical Research Council Laboratory Animal Center, Carshalton, Surrey, United Kingdom, 1956.
Malacara, H.J.M.: Bases para la Investigación Biomédica. Distribuidora y Editora Mexicana, México, D.F., 1987.
Poole, T.B.: Raising and defining laboratory animals. In: The UFAW Handbook on the Care and Management of Laboratory Animals. 6th ed. Edited by: Poole, T.B., 2-7. Longman Scientific and Technical, London, 1987.
Schunemann, AA.: La experimentación científica en animales de laboratorio. Gaceta Méd. Méx., 123: 247-259 (1987).
Universities Federation for Animal Welfare: The Handbook on the Care and Management of Laboratory Animals. 6th ed. Longman Scientific and Technical, London, 1987.
Working Committee for the Biological Characterization of Laboratory Animals. Laboratory Animals Science Association/GV-SOLAS: Guidelines for specification of animals and husbandry methods when reporting the results of animal experiments. Lab. Anim., 19: 106-108 (1985).