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2009, Number 3

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Rev Endocrinol Nutr 2009; 17 (3)

Diastolic dysfunction in hyperthyroidism

Molina-Ayala M, Castro-González LG, Orihuela-Rodríguez O, Mercado M

Language: Spanish
References: 13
Page: 103-106
PDF size: 85.54 Kb.


ABSTRACT

Background: In patients with hyperthyroidism, the deterioration in diastolic function can be explained by the non-adaptive effect of left ventricular hypertrophy and myocardial relaxation, which may affect the elasticity of the left ventricle (LV) and the atrioventricular coordination and eventually cause pericardial restriction. Objective: To determine the alterations in diastolic function in patients with hyperthyroidism. Material and methods: 27 patients with hyperthyroidism were included in the study. They all underwent Doppler, M-mode and two-dimensional echocardiography. Diastolic function was assessed by determination of the TRIVI (time of left ventricular relaxation), the E/A ratio, the deceleration time of the E wave and the E and A wave velocities. Results:Diastolic dysfunction was found in 11 of the 27 patients. In 9 this dysfunction became evident as a series of abnormalities in the relaxation of the LV, whereas in 2 it presented as a pseudo-normalized pattern. Free T4 levels were significantly higher in patients without diastolic dysfunction. Four of the 5 patients with subclinical hyperthyroidism had evidence of diastolic dysfunction. Conclusions: Besides the well-known hyperdynamic state, diastolic dysfunction of the left ventricle is a common finding in patients with endogenous hyperthyroidism, be it clinical or subclinical.


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