Briones GJC, Díaz LPMA, Loiseau AH, Briones VCG

Language: Spanish
References: 9
Page: 30-34
PDF size: 78.39 Kb.

ABSTRACT

Introduction: In 1926 was proposed creatinine clearance as an indicator of kidney function, we use at present in patients acute. In 1968 was isolated from the urine of Wilson, characterized by proximal tubular damage disease patients the Beta 2 (MGB₂) microglobulin, a polypeptide low molecular weight, this increase is verifiable in situations by the glomerular filtration decrease, what makes useful in the detection of tubular dysfunctions proximal.
Objective: Presented the results of the determination of beta 2 microglobulin and its correlation with creatinine clearance in obstetric patients with renal failure acute.
Material and methods: A prospective, comparative study was designed and cross-cutting of a series of 29 cases and contrasted with 40 controls. Is proceeded to the quantification and calculation of the creatinine debugging according the technique described originally with creatinine UP calculation by vol/Min. Likewise, peripheral blood samples were taken to make the determination serum Beta 2 Microglobulin with the technique of immunoassay, Lives, BioMeriéux Mexico (ELFA: Enzyme Linked fluorescent Assay).
Results: Using the formula for the linear correlation coefficient obtained a correlation refusal with r = - 0.72, has a 93% sensitivity and specificity of the 100% according to the calculation using the table of 2 x 2.
Conclusions: Beta 2 microglobulin the diagnosis of be fast is reliable, because it shows a high sensitivity and specificity and promises to become the standard of gold.

REFERENCES

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