2010, Number 1
Differentiated thyroid carcinoma at the Hospital de Especialidades, Centro Médico Nacional Siglo XXI, IMSS: Analysis focusing on stimulated thyroglobulin levels according to risk groups
Hernández-Martínez AF, Hernández-García I, Jervis-Solines P, Hidalgo-Funes L, Ramírez-Rentería C, Mercado M
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Language: Spanish
References: 7
Page: 6-10
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ABSTRACT
Introduction: Differentiated thyroid cancer (DTC) is the most common endocrine malignancy and its follow-up using stimulated thyroglobulin (sTg)) is of great utility. Several classifications have been proposed trying to identify risk factors associated with persistence, recurrence and mortality for this cancer. Objective: To describe the demographic characteristics of a subset of our patients with DTC and evaluate the relationship between the TNM classification and the Risk Classification Guidelines proposed by the Mexican Society of Nutrition and Endocrinology (SMNE) (modified) with sTg after one year of initial treatment. Material and methods: Clinical and pathologic data of 150 patients were recorded, and both classifications were applied. A sub-analysis was performed in 67 patients who had sTg measurements available, in the absence of Tg antibodies after one year of initial treatment. Results: The TNM system classified 80.5% of the patients in stages I and II; the highest sTg evel (median 34.7 ng/mL) was found in a group of 7 subjects (10.4%) who were categorized as stage IV A. In contrast, using the risk stratification system of the SMNE 49.3% of the patients were categorized as high risk, regardless of age (younger or older than 45) or sTg level. Conclusions: The apparent discrepancies between these 2 classification systems found in the present study highlight the importance of an individualized assessment of patients with DTC.REFERENCES