2010, Number 1
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ABSTRACTDengue virus (DV) infections are a serious cause of morbidity and mortality in most tropical and subtropical areas of the world. Dengue virus infection can be asymptomatic or causes two forms of illness, dengue fever (DF) and dengue hemorrhagic fever (DHF), which is the severe form of dengue illness and often fatal. In subsequent infection with a dengue virus of different serotype, severe disease is linked to high levels of antibody-enhanced viral replication early in illness which is followed by a cascade of memory T-cell activation, other cells of immune system and a production of inflammatory cytokines and other chemical mediators that cause an increase in vascular permeability. Advances in that field of immunology have shown that DHF/DSS pathogenesis is a complex, multifactorial process related with host and viral factors that influence disease severity.
Lai CJ, Goncalvez AP, Men R, Wernly C, Donau O, Engle RE, Purcell RH. Epitope determinants of a chimpanzee dengue virus type 4 (DENV-4)-neutralizing antibody and protection against DENV-4 challenge in mice and rhesus monkeys by passively transferred humanized antibody. J Virol 2007; 81(23): 12766-74. Epub 2007 Sep 19.