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ISSN 1405-0099 (Print)

2000, Number 1

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Cir Gen 2000; 22 (1)

Locally recurring breast carcinoma

Cantú LD, López GCM

Language: Spanish
References: 30
Page: 62-68
PDF size: 59.65 Kb.


ABSTRACT

Introduction: Carcinoma of the breast is the second most frequent neoplasia in women, local recurrence is the most representative sign of treatment failure. There are, however, a large variety of approaches to the management of recurring breast cancer.
Setting: Third level health care hospital.
Objective: To review the literature regarding the main therapeutic measures to handle local or regional recurrences, the natural history of recurrences, and to analyze current therapeutic tendencies.
Methods: We reviewed the literature from 1951 to 1996 on therapeutic research for the handling of local or systemic recurrence of breast cancer. The MEDLINE Data Base was used to locate and choose the reading material (30 references).
Results: Recurrences are the main challenge faced by the medical personnel treating breast cancer; approximately 20% of the patients subjected to modified radical mastectomy and 18% of those treated with conservative surgery will present local recurrences. Global survival after recurrence at 5 years is of 20 to 40%. A second local/regional recurrence has been informed in 65% of the patients. Most first choice treatments are aimed at controlling the disease; this includes re-excision, with or without radiotherapy, to systemic treatment with cytotoxic drugs.
Conclusion: The review showed that the local/regional recurrences are frequently interpreted as a sign of systemic disease, and therefore the first choice treatment has to be systemic using chemotherapy, however, in isolated cases of local/regional recurrences at the suprascapular ganglionar level, axilary or thoracic wall , there are alternatives, such as surgical resection with or without radiotherapy, and in very selected cases radiotherapy alone.


REFERENCES

  1. Kennedy MJ, Abeloff MD. Management of locally recurrent breast cancer. Cancer 1993; 71: 2395-409.

  2. Donegan WL, Perez-Mesa CM, Watson FR. A biostatistical study of locally recurrent breast carcinoma. Surg Gynecol Obstet 1966; 112: 529-40.

  3. Brower ST, Weinberg H, Tartter PI, Camunas J. Chest wall resection for locally recurrent breast cancer: indications, technique, and results. J Surg Oncol 1992; 49: 189-95.

  4. Dahlstrom KK, Andersson AP, Andersen M, Krag C. Wide local excision of recurrent breast cancer in the thoracic wall. Cancer 1993; 72: 774-7.

  5. Miyauchi K, Koyama H, Noguchi S, Inaji H, Yamamoto H, Kodama K, et al. Surgical treatment for chest wall recurrence of breast cancer. Eur J Cancer 1992;28ª:1059-62.

  6. Demaree EW. Local recurrence following surgery for cancer of the breast. Ann Surg 1951; 134: 863-7.

  7. Kurtz JM, Amalric R, Brandone H, Ayme Y, Jacquemier J, Pietra JC, et al. Local recurrence after breast-conserving surgery and radiotherapy. Frequency, time course, and prognosis. Cancer 1989; 63: 1912-17.

  8. Reid IM, Donohue JH. The biological significance of locoregional recurrence following breast conserving therapy. Semin Surg Oncol 1992; 8: 113-16.

  9. Harris JR, Recht A, Amalric R, Calle R, Clark RM, Reid JG, et al. Time course and prognosis of local recurrence following primary radiation therapy for early breast cancer. J Clin Oncol 1984; 2: 37-41.

  10. Chauvet B, Reynaud-Bougnoux A, Calais G, Danel N, Lansac J, Bougnoux P, et al. Prognostic significance of breast relapse after conservative treatment in node-negative early breast cancer. Int J Radiat Oncol Biol Phys 1990; 19: 1125-30.

  11. Hathaway CL, Rand RP, Moe R, Marchioro T. Salvage surgery for locally advanced and locally recurrent breast cancer. Arch Surg 1994; 129: 582-7.

  12. Toi M, Tanaka S, Bando M, Hayashi K, Tominaga T. Outcome of surgical resection for chest wall recurrence in breast cancer patients. J Surg Oncol 1997; 64: 23-6.

  13. Snyder AF, Farrow GM, Masson JK, Payne WS. Chest-wall resection for locally recurrence of breast cancer. Arch Surg 1968; 97: 246-53.

  14. Kluiber R, Bines S, Bradley C, Faber LP, Witt TR. Major chest wall resection for recurrent breast carcinoma. Am Surgeon 1991; 57: 523-9; discussion 529-30.

  15. Veronesi U, Cascinelli N, Bufalino R, Morabito A, Greco M, Galluzo D, et al. Risk of internal mammary lymph node metastases and its relevance on prognosis of breast cancer patients. Ann Surg 1984; 198: 681-4.

  16. Veronesi U, Salvadori B, Luini A, Banfi A, Zucali R, DelVecchio M, et al. Conservative treatment of early breast cancer. Long-term results of 1232 cases treated with quadrantectomy, axillary dissection, and radiotherapy. Ann Surg 1990; 211: 250-9.

  17. Vicini FA, Recht A, Abner A, Boyages J, Cady B, Connolly JL, et al. Recurrence in the breast following conservative surgery and radiation therapy for early-stage breast cancer. Monogr Natl Cancer Inst 1992; 11: 33-9.

  18. Fisher B, Anderson S, Fisher ER, Redmound C, Wickerham DL, Wolmark N, et al. Significance of ipsilateral breast tumor recurrence after lumpectomy (see comments). Lancet 1991; 338: 327-31.

  19. Halverson KJ, Perez CA, Kuske RR, Garcia DM, Simpson JR, Fineberg B. Survival following locoregional recurrence of breast cancer: univariate and multivariate analysis. Int J Radiat Oncol Biol Phys 1992; 23: 285-91.

  20. Kutz JM, Amalric R, Brandone H, Ayme Y, Spitalier JM. Results of salvage surgery for mammary recurrence following breast-conserving therapy. Ann surg 1988; 207: 347-51.

  21. Wilson RE. Surgical management of locally advanced and recurrent breast cancer. Cancer 1984; 53: 752-7.

  22. Haffty BG, Fischer D, Rose M, Beinfield M, McKhann C. Prognostic factors for local recurrence in the conservatively treated breast cancer patient: a cautious interpretation of the data. J Clin Oncol 1991; 9: 997-1003.

  23. Spearman MP, Scola FH, Schepps B. Detection of chest wall and axillary breast cancer recurrence after mastectomy. Breast Dis 1993; 6: 211-214.

  24. Fourquet A, Campana F, Zafrani B, Mosseri V, Vielh P, Durand JC, et al. Prognostic factors of breast recurrence in the conservative management of early breast cancer: a 25-year follow-up. Int J Radiat Oncol Biol Phys 1989; 17: 719-25.

  25. Chu FC, Lin FJ, Kim JH, Huh SH, Garmatis CJ. Locally recurrent carcinoma of the breast. Results of radiation therapy. Cancer 1976; 37: 2677-81.

  26. Hortobagyi GN. Comprehensive management of locally advanced breast cancer. Cancer 1990; 66: 1378-91.

  27. McKenna RJ Jr, McMurtrey MJ, Larson DL, Mountain CF. A perspective on chest wall resection in patients with breast cancer. Ann Thorac Surg 1984; 38: 482-7.

  28. Singletary SE, McNeese MD, Hortobagyi GN. Feasibility of breast-conservation surgery after induction chemotherapy for locally advanced breast carcinoma. Cancer 1992; 69: 2849-52.

  29. Capri G, Tarenzi E, Fulfaro F, Gianni L. The role of taxanes in the treatment of breast cancer. Semin Oncol 1996; 23(1suppl 2): 68-75.

  30. Spicer D, Pike MC, Henderson BE. The question of estrogen replacement therapy in patients with a prior diagnosis of breast cancer (see comments). Oncology Huntingt 1990; 4: 49-54,59; discussion 59,62.




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