Katia A Jáuregui Luna, Xóchitl García Samper, Óscar Contreras Rivas, Emilio de J Castillo Hernández, María Elena Hernández G, Armando Medina González, Soto CJ

Language: Spanish
References: 10
Page: 138-139
PDF size: 353.06 Kb.

ABSTRACT

Primary biliary cirrhosis (PBC) disease of unknown origin produce intrahepatic progressive bile ducts destruction and predominates on women. Diagnosis is based on the clinical picture, serology with antimitochondrials antibodies (AMA) which are positive on 95% of the cases and histopathologic examination. Clinical case. Femenine sex 36 years old without important antecedents. Illness began four years before with fatigue, progressive jaundice, generalized pruritus and hepatoesplenomegaly. Laboratory: blood count, serum chemistry, serum electrolytes, coagulation tests, reactive C protein, sedimentation and rheumatoid factor all normal. Hepatomegaly, was confirmed by sonography and tomography in an otherwise normal abdomen. Direct bilirrubine increased, 9 mg, and indirect 4.2; aminotransferasas enzymas increased, AST=612 ALT=408 units; cholesterol 255mg/dL, alkaline phosphatasa 334, LE cells positive, antinuclear antibodies and anti-smooth muscle smooth positive, AMA and hepatitis viral serology negative. Histopathological signs of ductal injury and retrograde endoscopic cholangiopancreatography normal. Diagnosis of PBC stadium 1 (according to Scheuer) with AMA negative. Evolution. Treatment with ursodesoxicholic acid, colchicine, and colestiramine, decreased the jaundice and disappeared pruritus, although six months later enzymas were still high.

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