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2010, Number 5

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Med Int Mex 2010; 26 (5)

Intraspinal malignant melanoma in pregnancy: Report a case

Pelayo-Nieto M, Ruvalcaba-Ortega L, Prieto-Miranda SE, Vélez- Gómez E, López-Elizalde R
Full text How to cite this article

Language: Spanish
References: 8
Page: 508-511
PDF size: 234.07 Kb.


Key words:

Pregnancy, Intraspinal malignant melanoma, Central Nervous System, Cauda Equine Syndrome.

ABSTRACT

The central nervous system melanoma represents 1% of all melanoma cases and only 10% of malignant melanomas in this site are primary. The first case of primary spinal melanoma was described in 1960 and to date, this lesion is extremely rare. We report a case of intraspinal melanoma in a young, pregnant woman, without associated risk factors. This clinical-pathological presentation has not been described before in the sources reviewed.
This clinical case is about a 23 year old woman with 28 weeks of pregnancy, admitted with dyspnea and flaccid paraparesis, the clinical history and medical examination were compatible with cauda equine syndrome. MRI identified a neoplasm at S1-S3. In surgery we found a deep black intraspinal tumor, infiltrating paravertebral structures, not viable for excision. The histopathological report confirmed malignant melanoma.
Conclusions: 2-5% of all primary melanomas do not come from skin. We present a pregnant patient with an intraspinal melanoma, in which a source could not be identified. The reviewed literature does not confirm a relationship between extra-cutaneous melanoma and pregnancy.
We reported a clinical situation with a very low incidence and we concluded the diagnosis of intraspinal melanoma as a probable primary malignancy.


REFERENCES

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  2. Salame K, Merimsky O, Yosipov J, Reider-Groswasser I, Chaitchik S, Ouaknine GE. Primary intramedullary spinal melanoma: Diagnostic and treatment problems. J Neurooncol 1998;36:79-83.

  3. Francois P, Lioret E, Jan M. Primary spinal melanoma: Case report. Br J Neurosurg 1998;12(2):179-182.

  4. Lee CJ, Rhee DY, Heo W, Park HS. Primary leptomeningeal malignant melanoma. J Korean Neurosurg Soc 2004;36:425-427.

  5. Farrokh D, Fransen P, Faverly D. MR findings of a primary intramedullary malignant melanoma: Case report and literature review. Am J Neuroradiol 2001;22:1864-1866.

  6. Hayward RD. Malignant melanoma and the central nervous system. J Neurol Neurosurg Psychiatry 1976;39:526-530.

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  8. Larson TC, Houser OW, Onofrio BM, Piepgras DG. Primary spinal melanoma. J Neurosurg 1987;66:47-49.




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Med Int Mex. 2010;26