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Colegio de Medicina Interna de México.
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2010, Number 5

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Med Int Mex 2010; 26 (5)

Diabetes mellitus and its association with pancreatic cancer in the elderly: a case report and literature review

Bourlon CR, Martínez BM, Moreira VW, Salcido PP, Vázquez GP
Full text How to cite this article

Language: Spanish
References: 8
Page: 512-515
PDF size: 190.54 Kb.


Key words:

Diabetes Mellitus, Pancreatic Neoplasm, Beta cells.

ABSTRACT

The relationship between Diabetes Mellitus and Pancreatic Neoplasm has been a reason of discussion for several years. In about 50% of patients first studied for Sporadic Pancreatic Neoplasm the diagnosis of Diabetes Mellitus has been found, of which half are diagnosed at the same time, or briefly after. There is an eight fold time risk for developing Pancreatic Neoplasm in elderly with recent diagnosis of Diabetes Mellitus. The association between these two entities is not fully understood. It is thought that it may be in relation to glandular destruction by the tumor. It is suggested that the Beta cells dysfunction is the primary pathogenic defect associated. Because of its low incidence, the early diagnosis it’s not done, and in consequence has a poor prognosis.


REFERENCES

  1. Lerch MM, Zenker M. Developmental and metabolic disorders of the pancreas. endocrinology and metabolism. Clinics of North America 2006;35:219-241.

  2. Keiji H, Fumiki H. Current treatment strategies for pancreatic cancer in the elderly. Drugs 2006;23(5):603-661.

  3. Hornick T, Aron DC. Managing diabetes in the elderly Go easy, individualize.

  4. Peter S, Spilcke E. Endocrine tumors of the pancreas. Endocronology and Metabolism Clinics of North America 2006;35:431-447.

  5. Pezilli R, Casadei R, Morselli-Labale S. Is Type 2 Diabetes a risk factor for pancreatic cancer? JPancreas 2009;10(6):705-706.

  6. Pannala R, Ananda B, Peterson G, et al. New-onset Diabetes: a potential clue to the early diagnosis of pancreatic cancer. Lancet Oncol 2009;10(1):88-75.

  7. Chari ST, Leibson CL, Rabe KG, et al. Pancreatic cancerassociated Diabetes Mellitus: Prevalence and temporal association with diagnosis of cancer. Gastroenterology 2008; 134(1):95-101.

  8. Pannala R, Leirness JB, Bamlet WR, et al. Prevalence and clinical profile of pancreatic cancer-associated diabetes mellitus. Gastroenterology 2008;134(4):981-987.




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Med Int Mex. 2010;26