Portilla RJ, Domínguez LG, Gaitán CLA, Gutiérrez VG, Pinzón TME, León AJ, Sánchez HF

Language: Spanish
References: 29
Page: 65-71
PDF size: 491.29 Kb.

ABSTRACT

According to the literature, Xylitol has certain anti-dental biofilm properties, primarily, an ability to impede its formation, whilst inhibiting the reproduction of cariogenic bacteria and their capacity to adhere to enamel; when used in chewing gum, it can be a contributing factor in the prevention of dental caries and gingivitis. It is the most studied artificial sweetener, yet opinions as to its effects are divided. To the best of our knowledge, no studies that take into account geographical, genetic and dietary differences or variations in customs and environment have been published in Mexico. A randomized, clinical, double-blind study was carried out amongst student volunteers at the Faculty of Dentistry of Mexico’s UNAM university, which included a control group who stopped brushing their teeth for a period of seven days, and a test group of students who, in addition, used a chewing gum containing Xylitol (TRIDENT VAL-U-PACK®). Probing for gingival bleeding in the experimental group showed, at day 0, an average value of 10.31%, and at day 7, a value of 26.45%, representing a 64.2% increase; meanwhile, the corresponding values for the control group were 9.56% at day 0, and 24.45% at day 7, i.e. an increase of 176.6%, and a difference of 112% between the two groups. The difference in biofilm accumulation was even more marked: in the control group an increase of 17.94% was observed, whereas in the experimental group there was actually a reduction of 4.6%. No significant differences were observed in microorganism colony count (UFC) or in the pH values of saliva.

REFERENCES

1. Zaura, E. Dental Plaque as a Biofilm: A Pilot study of the effect of Nutrients on Plaque pH an dentin Demineralization. Caries Research, 2004;38 (suppl 1):9-15.

2. Marsh PD. Plaque as a biofilm: pharmacological principles of drug delivery and action in the sub-and supra gingival environment. Oral Dis 2003;9 (suppl1):16-22.

3. Benchabane H, Lortie L, Buckley N.D, Trahan L, Freneltte M. Inactivation of the Streptococcus mutans fxpC gene confers resistance to xylitol, a caries-preventive natural carbohydrate sweetener. J Dent Res 2002;81:380-6.

4. Söderling E, Isokangas P, Pienihäkkinen K, Tenovuo J. Influence of Maternal xylitol consumptions on acquisition of mutans streptocci by infants. J Dent Res. 2000;79:882-7.

5. Lif Holgerson P, Stecksen-Blicks C, Sjöstrom I, Öberg M, Twetman S. Xylitol concentration in saliva and dental plaque after use of various xylitol-containing products. Caries Research 2006;40:393-7.

6. Peldyak J.,Mäkinen K. ,Xylitol for Caries Prevention., The Journal for Dental Hygiene. 2002;(76,-IV)276-84.

7. Mäkinen KK, Bennett CA, Hujoel PH, et.al: Xylitol chewing gums and caries rates: a 40-month cohort study. J Dent Res 1995;74:1904-13

8. Zero DT. Are sugars substitutes also cariogenic? JADA 2008; (139)9s-10s.

9. Milgrom P, Ly KA, Roberts MC, Rothen M, Muller H, Yamaguchi DK. Mutans streptococci dose response to Xylitol chewing gum. J Dent Res 2006;137(2):190-6.

10. Declaración de Helsinki de la Asociación Médica Mundial, Arbor Ciencia, Pensamiento y Cultura. 2008;ISSN: 0210-1963.

11. Reglamento de la ley General de Salud. Título segundo, Capítulo I, Artículo 17.

12. Lif Holgerson P, Stecksen-Blicks C, Sjöstrom I, Öberg M, Twetman S. Dental plaque formation and salivary mutans streptococci in schoolchildren after use of xylitol-containing chewing gum. Journal of Paediatric Dentistry 2007;17:79-85.

13. Scheie A.A, Fejerskov, Danielsen B. The effects of xylitolcontaining chewing gums on dental plaque and acidogenic potential. J Dental Res 1998;77:1547-52.

14. Benchabane H, Lortie L, Buckley N.D, Trahan L, Freneltte M. Inactivation of the Streptococcus mutans fxpC gene confers resistance to xylitol, a caries-preventive natural carbohydrate sweetener. J Dent Res 2002;81:380-6.

15. Page RC, Schroeder HE. Pathogenesis of inflammatory periodontal disease. A summary of current works. Lab Invest 1976; 235-43.

16. Seymour GJ, Powell RN, Aitken JF. Experimental gingivitis in humans. A clinical and histologic investigation. J Periodotol 1983;54:522-29.

17. Loesche WJ, Syed S.A. Bacteriology of human experimental gingivitis: Effect of plaque and gingivitis score. Infection and Immunity 1978; 21:830-9.

18. Aguirre-Zero O DT, Proskin HM. Effect of chewing Xylitol chewing gum on salivary flow rate and the acidogenic potential of dental plaque. Caries Res 1993:27 (1):55-59

19. 1999 International workshop for a classification of periodontal diseases and conditions. Ann Periodontol/the American Academy of Periodontology. 1999;4:1-112.

20. Söldering E. The effect of Xylitol in dental biofilm. Adv Den Res 2009;21:74-8.

21. Zero DT, J Fu, Espeland MA, Featherstone JBD. Comparison of fluoride concentrations in unstimulated whole saliva following the use of fluoride dentrifice and fluoride rinse. J Dent Res 1988,9:214-30

22. Colin Dawes, Salivary flow patterns and the health of hard and soft oral tissues. JADA, 2008;139

23. Loesche WJ, Syed S.A. Bacteriology of human experimental gingivitis: Effect of plaque and gingivitis score. Infection and Immunity 1978;21:830-9.

24. Portilla R. J., Pinzón T. M.E., Huerta L E.R.,Obregón PA. Conceptos actuales e investigaciones futuras en el tratamiento de la caries dental y control de la placa bacteriana. 2009 (En prensa)

25. Navazesh, M, Kumar S, K, S. Measuring Salivary Flow: Challenges and Opportunities. JADA 2008;139: 35s-40s.

26. Ten Cate JM. Current concepts on the theories of the mechanism of action of fluoride. Acta Odontol Scand 1999;57(6):325-9

27. Zero DT. Sugars: the arch criminal? Caries Res 2004; 38(3) 277-85

28. Ten Cate JM, van Loveren C. Fluoride mechanisms. Dent Clin North Am 1999;43(4)713-42

29. Stookey G, The effect of saliva on dental caries JADA 2008;139.