Rodríguez-Hernández DM, Villalpando-Gómez Y, De la Cerda-Trujillo LF, Rocha-Muñoz AD, Fuentes-González C, Moreno-Sandoval IV, Castro-Contreras U, Salazar-Páramo M, González-López L, Gámez-Nava JI

Language: Spanish
References: 13
Page: 14-19
PDF size: 267.78 Kb.

ABSTRACT

Introduction: Ankylosing spondylitis (AS) is a chronic inflammatory disease that affects axial skeleton and can develop ankylosis. Is associated with vertebral fractures due to osteoporosis. In Mexico there is little information regarding the prevalence of bone mineral density (BMD) and osteoporosis in AS. Objective: To evaluate the frequency of low bone mineral density and osteoporosis in AS. Material and methods: Comparative cross. We identified 72 patients with AS compared to 59 clinically healthy subjects of similar age range and sex. Both groups were measured BMD by: DEXA in 3 regions: femoral neck, lumbar spine and radius 33%. χ² analysis to compare proportions and Mann-Whitney test to compare means. Results: Radius 33% low BMD was observed in 26% of AS patients compared to 12% of clinically healthy subjects (p = 0.03). Femoral neck BMD was observed in 29% lower compared to 19% AS in clinically healthy subjects (p = 0.2) and column 28 vs 25% (p = 0.10). Osteoporosis in any region was observed in 10% of AS compared with 2% in controls (p = 0.05). Conclusions: We conclude that the presence of low BMD at EA is greater than in controls favoring bone structural deterioration and increased risk of osteoporotic fracture, so early detection and effective use of therapeutic will decrease the probability of this event.

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