2011, Number 1
Patol Rev Latinoam 2011; 49 (1)
Brindis ZM, León BB, Cuesta MT, Ortiz HC
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ABSTRACTBackground: Calcifying fibrous pseudotumor is an uncommon clinical and pathological disease, which was described by Rosenthal and Abdul-Karim in 1988. It has been reported previously in soft tissues and in the pleura. Peritoneal calcifying fibrous pseudotumors were found in adults. It is characterized by a predominantly lymphoplasmacytic infiltrate with abundant hyalinized collagen and psamomatous or dystrophic calcifications. The cause and pathogenesis are unclear. It has been postulated that CFP may represent a sclerosing end stage of inflammatory myofibroblastic tumor.
Objective: To describe two cases of calcifying fibrous pseudotumor in visceral peritoneum.
Methods: We describe two cases of calcifying fibrous pseudotumor in visceral peritoneum, one in an 11-year-old boy and the other in a 70-year-old man with immunohistochemical analysis.
Results: Both cases presented similar histological findings to the ones described in the literature for the calcifying fibrous pseudotumor. These cases consisted of lesions covered by reactive mesothelium, not encapsulated, composed by dense bundles and sparse spindle collagen, vastly vascularized with sclerosis in the walls of the vessels evident with Masson stain, areas of dystrophic calcification (psamomatous), chronic inflammatory infiltrate with predominant lymphocytes and, in a lesser number, plasmatic cells. By immunohistochemistry both cases were positive for vimentin in fibroblast, blood vessels walls; the mesotelial cells were positive homogenous to the calretinina. CD 117 and CD 34 were negative and the proliferation index measure with Ki 67 were 0.