Ramírez MAH, Cabrera RAA, Rosas BJV, Núñez TNE, Plasencia RO, Villagomez OAJ, Méndez RR, Guzmán GR

Language: Spanish
References: 11
Page: 142-149
PDF size: 370.93 Kb.

ABSTRACT

Background: The microalbuminuria is a marker of systemic disease and endothelial injury, its determination has demonstrated to be useful to establish the prognosis in critical patients.
Material and methods: We develop an observational, longitudinal, prospective, descriptive study in the UCI of the Hospital 1° de Octubre, in 30 patients who entered to the UCI during 5 months (16 women and 14 men). We determine microalbuminuria by immunoassay with Microalbumin Flex® reagent cartridge to the admission, 8, 24 and 48 hours of entrance to the UCI. Scales of APACHE II and SOFA were correlated, sepsis, days of mechanical ventilation and stay in UCI with microalbuminuria. We made measures of central tendency, frequencies and dispersion, test with Mann-Whitney U and curves ROC for cut points.
Results: We found that the elevation of microalbuminuria in all the patients in the first 24 hours (51.69 ± 70.32 mg/Lt). In 6 septic patients who passed away the microal buminuria at the admission (98.5 mg/Lt, p = 0.0.024), 8 (89.08 mg/Lt, p = 0.05) and 24 hours (137.26 mg/Lt, p = 0.018) it was greater than in the survivors. APACHE II to the 8 hours, I am related to mortality (p = 0.026) and severe sepsis to the admission (p = 0.024). In curve ROC of APACHE II one was sensitivity of 80% and specificity of 84% with 21, 5 points.
Conclusion: The microalbuminuria is an early predicting factor of mortality in septic patients, is related to systemic inflammation by endothelial injury.

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