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Revista Mexicana de Urología

Organo Oficial de la Sociedad Mexicana de Urología
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2008, Number 4

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Rev Mex Urol 2008; 68 (4)

Five-year experience with ethamsylate in transurethral resection of the prostate

Molina-Polo LD, Aragón CM, Castillo HJ, Galicia SR
Full text How to cite this article

Language: Spanish
References: 13
Page: 199-202
PDF size: 99.17 Kb.


Key words:

ethamsylate, trans and postoperatory bleeding, transurethral resection of prostate.

ABSTRACT

The objective of the present work was to show both the usefulness of ethamsylate in diminishing peri- and postoperative bleeding in transurethral resection of the prostate and also to show how its application shortens hospitalization and the time necessary for postsurgical transurethral catheter to be used by the patient. A total of 146 patients presenting with normal preoperative hemoglobin count and no added pathology were studied. Postsurgical hemoglobin count was determined 24 hours after procedure and showed a mean decrease of 8.18% in gr/dl. The transurethral catheter was removed 24 hours after surgery in 97.27% of patients with no posterior bleeding. Ethamsylate application represents an important pre- and postoperative tool in transurethral resection of the prostate.


REFERENCES

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  2. Towler JM, Valerio D. Dicynene in transurethral resection of the prostate. Br J Urol 1978;50(7):547-50.

  3. Symes DM, Offen DN, Lyttle JA, Blandy JP. The effect of dicynene on blood loss during and after transurethral resection of the prostate. Br J Urol 1975;47(2):203-7.

  4. Garay RP, Chiavaroli C, Hannaert P. Therapeutic efficacy and mechanism of action of ethamsylate, a long-standing hemostatic agent. Am J Ther 2006;13(3):236-47.

  5. Hernandez MR, Alvarez-Guerra M, Escolar G, Chiavaroli C, Hannaert P, Garay RP. The hemostatic agent ethamsylate promotes platelet/ leukocyte aggregate formation in a model of vascular injury. Fundam Clin Pharmacol 2004;18(4):423-30.

  6. Alvarez-Guerra M, Hernandez MR, Escolar G, Chiavaroli C, Garay RP, Hannaert P. The hemostatic agent ethamsylate enhances P-selectin membrane expression in human platelets and cultured endothelial cells. Thromb Res 2002;107(6):329-35.

  7. Hutton RA, Wickham EA, Reed JV, Tuddenham EG. Studies on the action of ethamsylate (Dicynene) on haemostasis. Thromb Haemost 1986;56(1):6-8.

  8. Lewis GJ. Does ethamsylate increase the incidence of venous thrombosis? Br Med J (Clin Res Ed) 1984;288(6421):899-900.

  9. Okuma M, Takayama H, Sugiyama T, Sensaki S, Uchino H. Effects of etamsylate on platelet functions and arachidonic acid metabolism. Thromb Haemost 1982;48(3):330-3.

  10. Arnot RS, Rashid A, Evans M, Pollock AV. Proceedings: The haemostatic effect of ethamsylate (Dicynene) in general surgery. Br J Surg 1975;62(2):159.

  11. Garay RP, Chiavaroli C, Hannaert P. Therapeutic efficacy and mechanism of action of ethamsylate, a long-standing hemostatic agent. Am J Ther 2006;13(3):236-47.




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Rev Mex Urol. 2008;68