Corcho-Berdugo A, Muñoz-Hernández B, Palma-Cortés G, Ramírez-Hernández A, Martínez-Rivera M, Frías-de León M, Reyes-Montes M, Martínez-Valadez E, Manjarrez-Zavala M, Alfaro-Ramos L, Higuera-Iglesias AL

Language: Spanish
References: 12
Page: 377-384
PDF size: 104.64 Kb.

ABSTRACT

Objective: The aim of this study was to establish whether there was a histoplasmosis outbreak among a group of residents of Naucalpan (State of Mexico, a non-endemic area for histoplasmosis) and to ascertain the source through which they were infected. Material and methods: Anyone associated with the Index Case in the same period with a flu-like infection was considered as a suspected case. Diagnosis was confirmed by clinical examination positive, cultures and positive immunological tests. Date and form of potential exposure were obtained through interviews. Material potentially contaminated with bird or bat droppings was sought and analyzed by PCR. Results: The outbreak was associated with a trip to El Tamarindo (Veracruz, near the Gulf of Mexico). Patients got sick after digging a hole in the floor inside a house where a treasure had been supposedly buried by a death relative. The pathogen was detected in soil samples at 10 cm below the surface. Conclusions: The study showed that patients contracted histoplasmosis in El Tamarindo, a community where there had been no prior cases of this disease.

REFERENCES

1. Contreras C, Shibayama H, Gutiérrez P. Aportaciones del Instituto Nacional de Diagnóstico y Referencia Epidemiológica a la histoplasmosis. Rev Inst Nal Enf Respir Mex. 1998;11:216-20.

2. Vaca-Marin MA, Martínez-Rivera MA, Flores-Estrada JJ. Histoplasmosis en México, aspectos históricos y epidemiológicos. Rev Inst Nal Enf Resp Mex. 1998;11:208-15.

3. Velasco-Castrejón O. La histoplasmosis pulmonar primaria en México. Rev Inst Nal Enf Resp Mex. 1998;11:221-5.

4. Laniado-Laborín R. Coccidioidomycosis and other endemic mycoses in Mexico. Rev Iberoam Micol. 2007;24(4):249-58.

5. Taylor ML, Pérez-Mejía A, Yamamoto-Furusho JK, Granados J. Immunologic, genetic and social human risk factors associated to histoplasmosis: studies in the State of Guerrero, Mexico. Mycopathologia. 1997;138(3):137-42.

6. Reyes-Montes MR, Bobadilla M, Martínez-Rivera MA, et al. Relatedness analyses of Histoplasma capsulatum isolates from Mexican patients with AIDS-associated histoplasmosis by using histoplasmin electrophoretic profiles and randomly amplified polymorphic DNA patterns. J Clin Microbiol. 1999;37:1404-8.

7. Matos-Guedes HL, Jefferson Guimaraes A, Medeiros Muniz M, et al. PCR assay for identification of Histoplasma capsulatum based on the nucleotide sequence of the M antigen. J Clin Microbiol. 2003;41: 535-9.

8. Wheat JL. Histoplasmosis: a review for clinicians from non-endemic areas. Mycoses. 2006;49(4):274-82.

9. Morgan J, Cano MV, Feikin DR, et al. A large outbrake of Histoplasmosis among American travelers associated with a hotel in Acapulco, Mexico, Spring 2001. Am J Trop Med Hyg. 2003;69(6):663-9.

10. Taylor ML, Ruíz-Palacios GM, del Rocío Reyes-Montes M, et al. Identification of the infectious source of an unusual outbreak of histoplasmosis, in a hotel in Acapulco, state of Guerrero, Mexico. FEMS Immunol Med Microbiol. 2005;45(3):435-41.

11. Taylor ML, Chávez-Tapia CB, Rojas-Martínez A, et al.; Geographical distribution of genetic polymorphism of the pathogen Histoplasma capsulatum isolated from infected bats, captured in a central zone of Mexico. FEMS Immunol Med Microbiol. 2005;45(3):451-8.

12. Muñoz B, Martínez MA, Palma G, et al. Molecular characterization of Histoplasma capsulatum isolated from an outbreak in treasure hunters. BMC Infect Dis. 2010;10:264.