2011, Number 598
Eficacia de la terapia profiláctica en reducción de la migraña días/mes con el uso de gabapentina, topiramato y divalproex
Brenes NAE, Chan GKA
Full text
Language: Spanish
References: 14
Page: 277-282
PDF size: 343.66 Kb.
ABSTRACT
Migraine is a common episodic headache disorder. Patients with more than three painful crisis per month require prophylactic treatment, which generally is effective reducing the frequency and intensity of the crisis to about a half. The new options for preventive treatment mostly belong to the field of antiepileptic drugs. We performed a meta-analysis to show which treatment is most effective in reducing days/month of migraine using three anti-convulsants prophylactically. The results were obtained with Topiramate 100mg/day, Divalproex 500 mg-1.5g/day according to tolerance and Gabapentin 1800mg-2400mg/day. Twelve publications of the period 2001-2008 concluded that Topiramate was effective against placebo with an average seizure reduction of 3.85 days. Five studies published between 1995-2008 concluded that Divalproexwas effective against placebo reducing 2.958 days with migraine and three publications of the years 2001, 2002 and 2008 concluded that Gabapentin reduce an average of 1.9 days with migraine showing its effectiveness against placebo in the prophylaxis of migraine.REFERENCES
Departamento de Farmacoepidemiología. Tratamiento de Cefalea & Migraña. Caja Costarricense del Seguro Social. San José, Costa Rica. Tratamiento de Cefalea y Migraña en el Primer y Segundo Nivel de Atención. www.cochrane.ihcai.org/programa_seguridad_paciente_costa_rica/pdfs/33_Tratamiento-de-Cefalea-&-Migraña.