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Revista de Especialidades Médico-Quirúrgicas

Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado
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2005, Number 3

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Rev Esp Med Quir 2005; 10 (3)

Enfermedad de Creutzfeldt Jakob asociada a tiroiditis autoinmune: Reporte de un caso

Salas PG, Zavala RA, Aguilar NS, Gamiz MAL, Horta MSG, Vargas VE, López RL, De la Sancha MLM
Full text How to cite this article

Language: Spanish
References: 6
Page: 59-67
PDF size: 619.77 Kb.


Key words:

Spongiform encephalopathy, prions.

ABSTRACT

This is the case of a 70 year old male, with history of impair gait, auditory hallucinations, hypoacusis, diplopia, ptosis, dementia, and cerebellar syndrome for 6 months. The laboratory findings were, leukocytosis, increased hepatic enzymes, hypertonic hypovolemic hypernatremia, hypoalbuminemia, leukocyturia, bacteriuria, proteinuria, hyperglycorrhachia, progressive hypoxemia, and mixed acidosis. The antibodies anti-thyroglobulin and anti-peroxidase were high, also the protein 14-3-3. The diagnosis of encephalopathy spongiform and thyroiditis was made. He was treated with steroids, antibiotics, plasmapheresis and immunoglobulins. He evolved with a progressive neurologic deterioration and sepsis, dying after this. The diagnosis was corroborated by an autopsy, concluding with the diagnosis of Creutzfeldt-Jakob a sporadic variety and Autoimmune Thyroiditis.


REFERENCES

  1. Prusiner Stanley B.: Prion Diseases and the BSE Crisis, Science magazine, 1-17, 2005.

  2. Malmgren R. et al, Slow Transmissible Disease of the nervous System, Vol1, 93-112, 1979.

  3. Wilesmith J.W. Semin. Virology 2,239, 1991, Kimberlin R.H. in Bovine Spongiform Encephalopathy : The BSE Dilema, 165-75, 1996.

  4. Prusiner S.B. et al, J.Infection Disease, 167- 602, 1993.

  5. Prusiner Stanley B.: Prion Novel Infections Pathogens causing scrapie and Creutzfeldt Jakob Disease, 451-65, Academic Press Orlando Fl. 1987.

  6. Alpers M.P. The Central Nervous System some experimental models of Neurological Disease, O.T. Bayley and D. E. Smith Eds, 243-51,1968.




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Rev Esp Med Quir. 2005;10