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ISSN 1029-3035 (Electronic)

2011, Number 1

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Mediciego 2011; 17 (1)

Genetic and environmental factors contribution in hypertension development in studies of twins from Chambas town

del Rio AY, Castillo AD, Mayo MRC

Language: Spanish
References: 13
Page:
PDF size: 39.46 Kb.


ABSTRACT

ABSTRACT A cross-sectional observational study was carried out, in Chambas municipality, from February to April 2007 for describing the clinical, epidemiological and genealogical Hypertension behavior, identifying the contribution of genetic and environmental factors in the disease origin. The universe included 41 pairs of twins. The sample was composed of 33, where at least one member of pair suffered hypertension, 16 monozygotic and 17 dizygotic twins. Largest proportion of monozygotic agreed to hypertension. In both types of zygosity dominated 45 - 55 years and 65 years and older, white race; the average age of illness onset was before 50 years, particularly males. Among the risk factors highlighted a sedentary lifestyle, high-salt diet and smoking. Twins prevailed with first-degree relatives affected. The monozygotic concordance is 38%, 18% in dizygotic and the monozygotic probed was 54% and 30% dizygotic, 48% heritability. It concludes that the higher the proportion of genes shared in common, the greater is the likelihood of developing hypertension, and the importance of non-genetic risk factors for developing this disease.


REFERENCES

  1. Coca A, de la Sierra A. Hipertensión arterial y riesgo cardiovascular. JANO [Internet]. 2000 [citado 13 Ago 2003]; 58(134):40-44. Disponible en: http://db.doyma.es/cgi.exe/doyma/mrevista-jano.indice-revista?pident-revista-1

  2. Castellano J, La Rosa R, Curbelo Menéndez O. Prevalencia de la hipertensión arterial en una comunidad del municipio de Cárdenas. Rev Cubana Med. 2000; 16(2):138-143.

  3. Bases genéticas de la hipertensión arterial [Internet]. 2005 [citado 22 Feb 2007] [aprox. 3 pantallas]. Disponible en: http://www.saha.org.ar/Publico/herenciaHTA.htm

  4. Macias Belledo C, Lázaro Fernández E, Alcalá López J, Hernández Simón P. Etiología y fisiopatología de la hipertensión arterial esencial. Hosp Virgen Salud Toledo. 2003; 5: 141-160.

  5. Zenteno JC, Kofman Alfaro S. Aspectos genéticos de la hipertensión arterial. Rev Med Hosp Gen México. 2003; 4: 66.

  6. Madariaga MB. Hipertensión. Clin Nort Am. 1991; 2: 1165.

  7. Noa F, Castillo J, Heredero L, Castro J, Bacallao J, Rojas M. Factores genéticos y ambientales en pacientes con hipertensión arterial en una población urbana de Cuba. Arch INST Cardiol. MX. 2000; 65 (5): 426-34.

  8. Mueller RF, Young ID. Emery´s Genética Médica. 10a ed. Madrid: Marbán; 2001. P. 127-134, 213-216.

  9. Nicolaides KH, Falcón O. Ecografia en las 11-13 semanas. Embarazo múltiples. En: Nicolaides KH, Falcón O. Medicina Fetal. Londres: Fundación de Londres; 2004. p.101- 103.

  10. Huerta RB. Factores de riesgo para la hipertensión arterial. Arch Cardiol Mexico [Internet]. 2001 [citado 20 Ene 2010]; 71(Supl. 1): S208-S210. Disponible en: http://new.medigraphic.com/cgi-bin/resumenMain.cgi?IDARTICULO=10762

  11. Coronary disease and arterial hypretension. Editorial. Netherland Cardiol. 2002; 30(8):5.

  12. Oparil S. Hipertensión arterial. En: Bennet JC, Plu F, editores. Cecil. Tratado de Medicina Interna. Ciudad de la Habana: Editorial Ciencias Médicas; 1998. p. 294-330.

  13. Hottenga JJ, Whitfield JB, de Geus EJ, Boomsma DI, Martin NG. Heritability and stability of resting blood pressure in Australia twins. Twin Res Hum Genet. 2006; 9(2): 205-9.




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