medigraphic.com
ISSN 3061-8142 (Electronic)
ISSN 0484-7903 (Print)

2012, Number 1

<< Back Next >>

Rev Mex Anest 2012; 35 (1)

Aprepitant versus ondansetron in preventing postoperative nausea and vomiting in patients undergoing open cholecystectomy

Alonso-Damián ER, Anguiano-García MM

Language: Spanish
References: 24
Page: 8-14
PDF size: 105.79 Kb.


ABSTRACT

Objective: Determine whether aprepitant is superior to ondansetron in preventing postoperative nausea and vomiting in patients undergoing open cholecystectomy under general anesthesia. Material and methods: Included 60 patients aged 18 years randomly assigned to two groups, one group received 80 mg aprepitant orally and the other intravenous ondansetron 4 mg before induction of anesthesia. Documented episodes of nausea and vomiting to get to the recovery room, at 6 and 24 hours postoperatively. Results: Aprepitant group had better control of nausea upon arrival in the recovery room and 6 hours after surgery, with results similar to ondansetron at 24 hours. Conclusion: Aprepitant is superior to ondansetron in preventing postoperative nausea and vomiting in patients undergoing open cholecystectomy.


REFERENCES

  1. Machatuta NA, Paech MJ. Management of postoperative nausea and vomiting: focus on palonosetron. Therapeutics and Clinical Risk Management 2009;5:21-34.

  2. Lagos C, Quezada S. Profilaxis y tratamiento de las náuseas y vómitos postoperatorios. Rev Chil Anestesiol 2009;38:24-33.

  3. Singla NK, Singla SK, Chung FR, Kutsogiannis DJ, Blackburn L, Lane SR, et al. Phase II study to evaluate the safety and efficacy of the oral neurokinin-1 receptor antagonist casopitant (GW679769) administered with ondansetron for the prevention of postoperative and postdischarge nausea and vomiting in high-risk patients. Anesthesiology 2010;113:74-82.

  4. Diemunsch P, Joshi GP, Brichant JF. Neurokinin-1 receptor antagonists in the prevention of postoperative nausea and vomiting. Br J Anaesth 2009;103:7-13.

  5. Cordova R, Castro A, Bastidas A. Estudio comparativo de náusea y vómito postoperatorio. Rev Mex Anestesiol 2009;32:131-133.

  6. Scorza K, Williams A, Phillips JD, Shaw J. Evaluation of nausea and vomiting. American Family Physician 2007:76:76-84.

  7. Laalou FZ, Diemunsch P, Forestier C. Nausées et vomissements postopératoires. EMC Anesthésie-Réanimation 2007:36-423-A-10.

  8. Gan TJ. Risk factors for postoperative nausea and vomiting. Anesth Analg 2006;102:1884-1898.

  9. Oriol SA, Arzate PR, Hernández CE, Castelazo JA. ¿Ondansetrón o dexametasona? Tratamiento de náusea y vómito postoperatorios en cirugía abdominal. Rev Mex Anestesiol 2009;32:163-170.

  10. Rincón DA, Valero JF. Oxígeno suplementario para la prevención de la náusea y el vómito postoperatorios: meta-análisis de experimentos clínicos aleatorizados. Rev Esp Anestesiol Reanim 2008;55:101-109.

  11. Wengritzky R, Mettho T, Myles PS, Burke J, Kakos A. Development and validation of a postoperative nausea and vomiting intensity scale. Br J Anaesth 2009;104:158-166.

  12. Gan TJ, Meyer TA, Apfel CC, Chung F, Davis PJ, Habib AS. Society for ambulatory anesthesia guidelines for the management for postoperative nausea and vomiting. Anesth Analg 2007;105:1615-1628.

  13. McCracken G, Houston P, Lefebvre G. Guideline for the management of postoperative nausea and vomiting. J Obstet Gynaecol Can 2008; 30:600-607.

  14. Yun MJ, Kim YH, Kim AR. Comparison of azasetron and ondansetron for preventing postoperative nausea and vomiting in patients undergoing gynecological laparoscopic surgery. Yonsei Med J 2010;51:88-92.

  15. Gan TJ, Candiotti KA, Klein SM, Rodríguez Y, Nielsen KC, White WD, et al. Double-blind comparison of granisetron, promethazine, or a combination of both for the prevention of postoperative nausea and vomiting in females undergoing outpatient laparoscopies. Can J Anesth 2010;56:829-836.

  16. George E, Hornuss C, Apfel CC. Neurokinin-1 and novel serotonin antagonists for postoperative and postdischarge nausea and vomiting. Curr Opin Anesthesiology 2010;23:714-721.

  17. Diemunsch P, Gan TJ, Phillip BK, Girao MJ, Eberhart L, Irwin MG. Single-dose aprepitant vs ondansetron for the prevention of postoperative nausea and vomiting: a randomized, double-blind Phase III trial in patients undergoing open abdominal surgery. Br J Anaesth 2007;99:202-211.

  18. Rowbotham DJ. Neurokinin-1 antagonist: a step change in prevention of postoperative nausea and vomiting?. Br J Anaesth 2009;103:5-6.

  19. Acosta F, García JA, Aguayo JL. Manejo de las náuseas y vómitos postoperatorios. Cir Esp 2010; 88:369-373.

  20. Whalen F, Sprung J, Burkle CM, Schroeder DR, Warner DO. Recent smoking behavior and postoperative nausea and vomiting. Anesth Analg 2006;103:70-75.

  21. Rincón DA, Valero JF. Prevención de la náusea y el vómito postoperatorios. Rev Col Anestesiol 2007;35:293-300.

  22. Gan TJ, Apfel CC, Kovac A, Philip BK, Singla N, Minkowitz H, et al. A Randomized, double-blind comparison of the NK-1 antagonist, aprepitant, versus ondansetron for the prevention of postoperative nausea and vomiting. Anesth Analg 2007;104:1082-1089.

  23. Chen CC, Lin CS, Ko YP, Hung YC, Lao HC, Hsu YW. Premedication with mirtazapine reduces preoperative anxiety and postoperative nausea and vomiting. Anesth Analg 2008;106:109-113.

  24. Chan MT, Choi KC, Gin T, Chui PT, Short TG, Yuen PM, et al. The additive interactions between ondansetron and droperidol for preventing postoperative nausea and vomiting. Anesth Analg 2006;103:1155-1162.




2020     |     www.medigraphic.com