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Órgano Oficial de la Asociación Dental Mexicana

2011, Number 6

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Rev ADM 2011; 68 (6)

Xerostomia (hyposalivation) secondary to the pharmacological treatment of the arterial hypertension

Ibáñez MNG,Aguilar DN,Piña LYB,Partida RE

Language: Spanish
References: 42
Page: 283-289
PDF size: 168.55 Kb.


ABSTRACT

Arterial hypertension is one of the most common diseases in older adults. Though a number of drugs are available to reduce its complications, many of these produce xerostomia, as well as other complications of the mouth.
Objective: To identify the relationship between antihypertensive drugs and hyposalivation.
Material and Methods: A descriptive, cross-sectional, observational study. The oral mucosa of patients diagnosed with arterial hypertension was examined at the Hospital López Mateos ISEM, in Toluca, Mexico; an oral Schirmer testwas carried out and the information entered in a database. Independence tests were performed between these variables using the x2 test.
Results: A sample of 87 patients was obtained, 50.57% of whom were women and 49.43% men, their average age being 66; 63.2% of the patients were treated with two or more drugs; the medications most commonly used by the patients were furosemide, enalapril and nifedipine; 88.51% of the patients examined presented hyposalivation.
Discussion: Xerostomia directly affects the comfort of the patient, leads to malnutrition, and reduces quality of life. A total of 84.62% of the patients presented hyposalivation, which indicates the need to initiate preventive treatment in all patients treated pharmacologically; polypharmacy significantly reduces salivary flow.
Conclusions: A number of effective drugs are available for the therapeutic management of arterial hypertension, almost all of which can cause alterations in the mouth. Hyposalivation is observed in almost all cases and cannot be avoided; however, it is possible to take preventive measurements to alleviate it.


REFERENCES

  1. INEGI. Dirección General de Estadística. Estadísticas Vitales 2007, http: //www.inegi.org.mx.

  2. Norma Oficial Mexicana NOM-030-SSA2-1999, Para la prevención, tratamiento y control de la hipertensión arterial.

  3. Bertram G, Katzung. Farmacología básica y clínica, 9° ed. México, D.F. Manual Moderno; 2005. pp. 1152.

  4. Castellanos JL, Díaz L y Gay O. Medicina en odontología. Manejo dental de pacientes con enfermedades sistémicas. 2a ed. México. Manual Moderno 2005, pp.540.

  5. Mahvash., How can oral health care providers determine if patients have dry mouth?. J Am Dent Assoc 2003;134:613-618.

  6. Domínguez S., et al. Efectos medicamentosos adversos frecuentes sobre la cavidad bucal, Boletín de Información Clínica Terapéutica 2006;15(3):1-4.

  7. Neville, Damm, Allen, Bouquot. Oral & Maxillofacial Patology. 3ª Ed. Philadelphia,USA. Saunders Company; 2004.

  8. Scully C., et al, Nicorandil can induce severe oral ulceration, Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2001;87:189-193. 289

  9. Formiga F, Mascaró J, Vidaller A, Pujol R. Xerostomía en el paciente anciano. Mult Gerontol 2003;13:24-28.

  10. Porter SR., Scully C., Path F., Hegarty AM. An update of the etiology and management of xerostomia. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2004;97:28-46.

  11. Mosqueda Taylor. Tópicos selectos de Oncología Bucal. 1ra ed. México, D.F. Planeación y desarrollo editorial; 2007.

  12. Bagán JV. Medicina Bucal. 2da ed. Valencia España. Editorial Medicina Oral;2010.

  13. Marques M., Chimenos E., Subirá C., Rodríguez M. y López J. Asociación de síndrome de boca ardiente con xerostomía y medicamentos. Med Oral Pathol Oral Cir Bucal 2005;10:301-8.

  14. Bagán JV, Ceballos A, Bermejo A, Aguirre JM, Peñarrocha M. Medicina Oral. Barcelona, España. Mason; 1995.

  15. Ibáñez N., López C., Piña B. Frecuencia de hiposalivación en pacientes geriátricos. Revista ADM 2009;5:56-60.

  16. Wong David T. Salivary Diagnostics. U.S. Wiley-Blackwell; 2008.

  17. López P, Bermejo A, Bagan JV, Pascual E. Comparison of a New Test for the Measurement of Resting Whole Saliva with the Training and the Swali Techniques. Braz Dent J 1996;7:81-86.

  18. Loesche J. Walter , et al. Assessing the relationship between dental disease and coronary heart Disease in Elderly U.S. Veterans. JADA 1998;129:301-311.

  19. Ruesga Z., et al, Cardiología, Vol I. México. Manual Moderno; 2005, pp.897.

  20. Streckfus C. Salivary function and hypertension, a review of the literature and a case report. J Am Dent Assoc 1995;1261012-1017.

  21. Mosqueda A., Luna K., Irigoyen M., Díaz M., Coll A. Efecto del clorhidrato de pilocarpina como estimulante de la producción salival en pacientes sometidos a radioterapia de cabeza y cuello. Med Oral 2004;9:204-11.

  22. INEGI. Dirección General de Estadística. Estadísticas Vitales 2007, http://www.inegi.org.mx.

  23. Norma Oficial Mexicana NOM-030-SSA2-1999, Para la prevención, tratamiento y control de la hipertensión arterial.

  24. Bertram G, Katzung. Farmacología básica y clínica, 9° ed. México, D.F. Manual Moderno; 2005. pp. 1152.

  25. Castellanos JL, Díaz L y Gay O. Medicina en odontología. Manejo dental de pacientes con enfermedades sistémicas. 2a ed. México. Manual Moderno 2005, pp.540.

  26. Mahvash., How can oral health care providers determine if patients have dry mouth?. J Am Dent Assoc 2003;134:613-618.

  27. Domínguez S., et al. Efectos medicamentosos adversos frecuentes sobre la cavidad bucal, Boletín de Información Clínica Terapéutica 2006;15(3):1-4.

  28. Neville, Damm, Allen, Bouquot. Oral & Maxillo facial Patology. 3ª Ed. Philadelphia,USA. Saunders Company; 2004.

  29. Scully C., et al, Nicorandil can induce severe oral ulceration, Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2001;87:189-193. 289

  30. Formiga F, Mascaró J, Vidaller A, Pujol R. Xerostomía en el paciente anciano. Mult Gerontol 2003;13:24-28.

  31. Porter SR., Scully C., Path F., Hegarty AM. An update of the etiology and management of xerostomia. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2004;97:28-46.

  32. Mosqueda Taylor. Tópicos selectos de Oncología Bucal. 1ra ed. México, D.F. Planeación y desarrollo editorial; 2007.

  33. Bagán JV. Medicina Bucal. 2da ed. Valencia España. Editorial Medicina Oral;2010.

  34. Marques M., Chimenos E., Subirá C., Rodríguez M. y López J. Asociación de síndrome de boca ardiente con xerostomía y medicamentos. Med Oral Pathol Oral Cir Bucal 2005;10:301-8.

  35. Bagán JV, Ceballos A, Bermejo A, Aguirre JM, Peñarrocha M. Medicina Oral. Barcelona, España. Mason; 1995.

  36. Ibáñez N., López C., Piña B. Frecuencia de hiposalivación en pacientes geriátricos. Revista ADM 2009;5:56-60.

  37. Wong David T. Salivary Diagnostics. U.S. Wiley-Blackwell; 2008.

  38. López P, Bermejo A, Bagan JV, Pascual E. Comparison of a New Test for the Measurement of Resting Whole Saliva with the Training and the Swali Techniques. Braz Dent J 1996;7:81-86.

  39. Loesche J. Walter , et al. Assessing the relationship between dental disease and coronary heart Disease in Elderly U.S. Veterans. JADA 1998;129:301-311.

  40. Ruesga Z., et al, Cardiología, Vol I. México. Manual Moderno; 2005, pp.897.

  41. Streckfus C. Salivary function and hypertension, a review of the literature and a case report. J Am Dent Assoc 1995;1261012-1017.

  42. Mosqueda A., Luna K., Irigoyen M., Díaz M., Coll A. Efecto del clorhidrato de pilocarpina como estimulante de la producción salival en pacientes sometidos a radioterapia de cabeza y cuello. Med Oral 2004;9:204-11.




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