Peñuelas-Acuña J, Oriol-López SA, Pérez-Terrazas H

Language: Spanish
References: 18
Page: 234-239
PDF size: 90.18 Kb.

ABSTRACT

The available non-depolarizing neuromuscular blockers (NDNMB), such as rocuronium bromide, have shown pharmacological features that allow their use with a wider security margin in-patients with terminal renal failure (TRF). To prove the effectiveness of rocuronium a prospective, descriptive, longitudinal, and experimental study was carried out in 18 patients with TRF. Measures were taken for action, duration, and recovery time of NDNMB produced with 0.600 mg/kg (2DE90) doses, total intravenous anesthesia of propofol + fentanyl, and 100% oxygen ventilation in patients subjected to Tenchkoff catheter placement. Results show the following: 65 sec average time for traqueal intubation; 30 min, recovery of 25-75%, and 40 min recovery 25-80%, which doubles that of the healthy patient; five patients were reverted and received an extra dose, and no recurarization cases were presented. It can be concluded that rocuronium has a good security margin for patients with TRF heaving in mind that elimination half-life is increased 100% and NMB monitoring is required.

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