Entrar/Registro  
HOME SPANISH
 
Cirugía y Cirujanos
   
MENU

Contents by Year, Volume and Issue

Table of Contents

General Information

Instructions for Authors

Message to Editor

Editorial Board






>Journals >Cirugía y Cirujanos >Year 2000, Issue 6


Peñuelas-Acuña J, Oriol-López SA, Pérez-Terrazas H
Rocuronium bromide in patients with terminal renal failure
Cir Cir 2000; 68 (6)

Language: Español
References: 18
Page: 234-239
PDF: 90.18 Kb.

[Full text - PDF]

ABSTRACT

The available non-depolarizing neuromuscular blockers (NDNMB), such as rocuronium bromide, have shown pharmacological features that allow their use with a wider security margin in-patients with terminal renal failure (TRF). To prove the effectiveness of rocuronium a prospective, descriptive, longitudinal, and experimental study was carried out in 18 patients with TRF. Measures were taken for action, duration, and recovery time of NDNMB produced with 0.600 mg/kg (2DE90) doses, total intravenous anesthesia of propofol + fentanyl, and 100% oxygen ventilation in patients subjected to Tenchkoff catheter placement. Results show the following: 65 sec average time for traqueal intubation; 30 min, recovery of 25-75%, and 40 min recovery 25-80%, which doubles that of the healthy patient; five patients were reverted and received an extra dose, and no recurarization cases were presented. It can be concluded that rocuronium has a good security margin for patients with TRF heaving in mind that elimination half-life is increased 100% and NMB monitoring is required.


Key words: , Rocuronium bromide, Terminal renal failure, Total intravenous anesthesia.


REFERENCES

  1. Brenner, Rector. Excreción de fármacos. 5ta. Ed. 1996. WB Saunders Company.

  2. Castro Tavares J, Lencastre L. Relaxantes musculares na insuficiência renal e trasplante renal. In: Alvarez Gómez JA Editors. Relajantes musculares. ELA; 1996: 359.

  3. Pineda Díaz MV, Alvarez Gómez JA. Rocuronio. In: Alvarez Gómez JA. Editors. Relajantes musculares de. ELA, 1996: 173.

  4. Shiraishi H, Suzuki H, Suzuki T, Katsumata N, Ogawua S. Fading responses in the evoked EMG after rocuronium in cats. Can J Anaesth 1994; 11(9): 9–15.

  5. Tian L, Mehta M P, Prior C, Marshall IG. Relative pre and postjunctional effects of a new vecuronium analogue, Org 9426, at the rat neuromuscular junction. Br J Anaesth 1992; 62: 284–287.

  6. Golpariani M, Ohta Y, Nagashima H, Goldiner PL, Foldes FF. Org. 9426 potentates neuromuscular blocking effects of other non depolarizing muscle relaxants in rats. Anaesth Analg 1990; 70: S131.

  7. Foldes FF, Nagashima H, Nguyen H, Ohta Y. The clinical pharmacology of Org 9426. In: Bowman WC et al. Editors. Neuromuscular blocking agents: past, present and future. Excerpta Médica Amsterdan,The Netherlands; 1990: 171–181.

  8. Magorian T, Flannery KB, Miller RD. Comparison of rocuronium, succinilcoline and vecuronium for rapid-sequence induction of anesthesia in adult patients. Anesthesiology 1993; 79: 913-918.

  9. Pollard BJ, Chetty MS, Wilson A, Healy TEJ. Intubation conditions and time course of action of low dose rocuronium bromide in day case dental surgery. Eur J Anesth 1995; 12(11): 81–83.

  10. Prien T, Zahn P, Menges M, Brussel T. 1 X ED90 dose of rocuronium bromide: tracheal intubation conditions and time course of action. Eur J Anesth 1995; 12(11): 85–90.

  11. Mirakhur RK. Safety aspects of neuromuscular block agents with special reference to rocuronium bromide. Eur J Anesth. 1994; 11(9): 133–140.

  12. Khuenl-Brady KS, Pomaroli A, Pühringer F, Mitterschiffthaler G, Koller J. The use of rocuronium (Org 9426) in patients with chronic renal failure. Anaesthesia 1993; 48: 873–875.

  13. Brugger AJ, Alvarez Gómez. In: Alvarez Gómez JA, editor Relajantes musculares. ELA; 1996: 231–242.

  14. Ghoenhein MM, Kramer E, Bannow R, Pandya H, Routh JI. Binding of d-Tubocurarine to plasma proteins in normal humans and in patients with hepatic or renal disease. Anesthesiology 1973; 39: 410–415.

  15. Foldes FF, Deery A. Protein binding of atracurium and other short-acting neuromuscular blocking agents and their interaction with human cholinesterase. Anesth 1983; 55: 315.

  16. Mayer M, Doenicke A, Hoffmann, Peter K. Onset and recovery of rocuronium and vecuronium under enfluorane anaesthesia. Br J Anaesth 1992;69: 511–512.

  17. Cooper RA, Mirakhur RK, Wierda JMKH, maddineni VR. Pharmacokinetics of rocuronium bromide in patients with and without renal failure. Eur J Anesth 1995; 12(S11): 43–44.

  18. Wierda JMKH, Proost JH, Schiere S, Hommes FDM. Pharmacokinetics and pharmacokinetic/dynamic relationship of rocuronium bromide in humans. Eur J Anesth 1994; 11(9): 66–74.






>Journals >Cirugía y Cirujanos >Year 2000, Issue 6
 

· Journal Index 
· Links 
       
Copyright 2010