Bennett-Guerrero E

Language: English
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Approximately 13.8 million units of allogeneic RBCs are administered in the US annually, with over 2 million units alone going to patients undergoing cardiovascular surgery. Allogeneic RBCs that are stored in modern preservative solutions are approved for use within 42 days after collection. This 42 day shelf life is based largely on the ability of these cells to persist in the circulation for › 24 hours. As previously summarized, it is well known that RBCs undergo significant biochemical and structural changes during the 42 day period of storage (e.g. decreased RBC deformability, decreased ATP and 2,3-DPG, and a significant increase in abnormally shaped RBCs).

REFERENCES

1. Ho J, Sibbald WJ, Chin-Yee IH. Effects of storage on efficacy of red cell transfusion: when is it not safe? Crit Care Med 2003;31:S687-97.

2. Bennett-Guerrero E, Veldman TH, Doctor A, et al. Evolution of adverse changes in stored RBCs. Proc Natl Acad Sci USA 2007;104:17063-8.

3. Koch CG, Li L, Sessler DI, et al. Duration of red-cell storage and complications after cardiac surgery. N Engl J Med 2008;358:1229-39.