2012, Number 2
Acta Pediatr Mex 2012; 33 (2)
Zaltzman-Girsevich S, Miranda-Ricardi E, Murata C, García-de la Puente S, Espino-Vela J
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ABSTRACTBackground. The treatment of arterial hypertension (AHT) based on the rennin level (Renin-Guided Treatment of Hypertension RGTH) is a valuable algorithm based on the physiological subtypes of this condition. Some authors suggest that the rennin level test should be included routinely as a useful guide for the treatment of AHT. However there is no information of its efficacy in pediatric practice.
Objective. Obtain retrospective information to decide whether a prospective study is justified in order to determine the efficacy of the above algorithm in children with AHT.
Material and method. A study of a comparative historic cohort based on the charts of hypertensive children studied at the Instituto Nacional de Pediatría (INP) was done. We recorded and compared the time required to normalize blood pressure in two groups of patients: one group (study Group) was treated following the RGHT algorithm. Another group (control Group) was treated with the conventional method. Variables influencing the time for control of AHT were recorded.
Results. There were 39 patients in the Study Group and 43 in the Control Group. Both groups were similar in age, and in systolic and diastolic arterial blood pressure. The time median to normalize arterial blood pressure in the Study Group was 44 hours (CS 95%: 40-50 hours) For the Control Group it was 89 hours (CS 95%: 72-82 hours). This difference was highly significant (Log-Rank: P = 0.0008).
Conclusions. A prospective study to determine the efficacy of RGHT algorithm in hypertensive children is justified.