2012, Number 1
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Rev Educ Bioquimica 2012; 31 (1)
Interleucina 17, funciones biológicas y su receptor
Flores-García Y, Talamás-Rohana P
Language: Spanish
References: 16
Page: 3-9
PDF size: 309.61 Kb.
ABSTRACT
Interleukin-17A (IL-17A) is the signature cytokine of the recently identified T helper 17 (Th17) cell subset. IL-17 has six family members (IL-17A to IL-17F). Although IL-17A and IL-17F share the highest amino acid sequence homology, they perform distinct functions; IL-17A is involved in the development of autoimmunity, inflammation, and tumors, and also plays important roles in the host defenses against bacterial and fungal infections, whereas IL-17F is mainly involved in mucosal host defense mechanisms. IL-17E (IL-25) is an amplifier of Th2 immune responses. The functions of IL-17B, IL-17C, and IL-17D remain largely elusive.
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