Figueroa-Sánchez GE, Arreola JM, Morales-Buenrostro LE

Language: Spanish
References: 9
Page: 22-28
PDF size: 130.08 Kb.

ABSTRACT

Introduction: Many of the risk factors (RF) for Urinary Tract Infection (UTI) which are found in the kidney transplant recipients (KTR) are the same that in general population, such as female gender, Diabetes Mellitus, Urinary tract anomalies and urinary tract catheterization, etc. Other specific factors related to the transplant itself, are: deceased donor, immunosupression, ureteric stent use, and urinary catheter. The objective of this study is to evaluate the RF for UTI during the early postransplant period in KTR and it’s relationship with graft and patient survival. Patients and methods: Retrospective cohort study. We included all kidney transplant performed at the Instituto Nacional de Nutrición «Salvador Zubirán» (INNSZ), during the period of 01/2008 to 12/2010. UTI was defined as the presence of ≥ 10⁵ CFU/mL in a urine culture. We included UTI’s that appeared in the first six months after kidney transplantation. We performed multivariate analysis of the RF for UTI. A p ‹ 0.05 was considered statistically significant. Results: A total of 143 KTR were included. The mean age was 34.14 years, with 45.5% of female gender. In 72% the allograft was obtained of a living donor. A 93.7% of KTR received induction therapy and 94.4% received Tacrolimus-Mofetil Micophenolate-Prednisone (TMP) as maintenance therapy. We found 84 episodes of UTI in 52 KTR, with a prevalence of 36.36%. The first UTI was observed during the first 10 postransplant days in 65.38% of patients. Multivariate analysis showed as independent RF for UTI: female gender (OR = 10.7, 95% CI 4.5-25.9, p ‹ 0.001) and Thymoglobulin induction therapy (OR = 4.2, 1.5-11.8, p = 0.006). We didn’t find any relationship between UTI and kidney rejection, allograft and patient survival. Conclusions: In this study, we found as RF for UTI: female gender and Thymoglobulin use. The acute rejection rate, the patient and allograft survival were not different between patients with and without UTI.

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