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2012, Number 6

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Rev Fac Med UNAM 2012; 55 (6)

Enteric fever in fastigium phase; epicritic notes on a necropsy case

Salazar MMF, Estrada HMR, Parraguirre MS

Language: Spanish
References: 28
Page: 26-34
PDF size: 381.32 Kb.


ABSTRACT

Typhoid fever is a multisystemic disease of infectious etiology with the gramnegative rod Salmonella typhi as its causative agent.
We present the case of a 19 year old woman who started with fever, abdominal cramps and diarrhea progressing to hepatic insufficiency, acute tubular necrosis, rhabdomyolysis and thrombocytopenia dying three days after hospital admission. Autopsy findings were as follows: Peyer´s patches ulcers, necrosis and inflammation of mesenteric lymph nodes, dotted ulcers in colon, lung hepatisation, hepatic, splenic and renal congestion, as well as purpuric lesions in mesencephalon and pons. Microscopic examination revealed macrophage clusters surrounding spots of necrosis (typhoid nodules) in the next locations: arachnoid mater, brain parenchyma, lung, liver, spleen, kidney and bone marrow. These findings supported a diagnosis of typhoid fever at fastigum stage. Typhoid fever goes through 5 consecutive stages whose morphological expression is product of several interactions between Salmonella typhi and the mononuclear phagocyte system of its host.


REFERENCES

  1. Ledermann DW. “Una historia del bacilo de Eberth desde Junker hasta Germanier”. Rev. chil. infectol. [online]. 2003; 20(suppl) [citado 2012-03-19];58-61.

  2. Navarro F. “Parentescos Sorprendentes: Tifus y estofado”. Disponible en: http://www.elcastellano.org/ns/edicion/ 2002/julio/parent12.html

  3. Brooks GF, Butel JS, Morse Sa. “The Salmonella-Arizona Group”. In: Brooks GF, Butel JS, Morse Sa. “ Jawtz, Melnick & Adelberg´s Medical Microbiology”. 23rd Edition, 2004 McGraw-Hill. Part III Bacteriology Chapter 16 Enteric Gram-negative Rods (Entero bacteriaceae). pp 256- 260.

  4. Murray PR, Rosenthal KS, Pfaller MA. “Salmonella”. In: Murray PR, Rosenthal KS, Pfaller MA. “Medical Microbiology”. 6th Edition 2009 Mosby Elsevier. Section 5 Bacteriology Chapter 30 Enterobacteriaceae. pp. 307-9.

  5. Romero Cabello R. “Microbiología y Parasitología Humana. Bases Etiológicas de las Enfermedades Infeccionas y Parasitarias”. 3ra Edición 2007 Editorial Médica Panamericana. pp 798-802.

  6. Smith JH. “Typhoid fever”. In: Connor DH, Chandler FW, et.al. “Pathology of Infectious Diseases”. Appleton & Lange 1997. Volume I Part III Bacterial Infections Chapter 93. p 875-887.

  7. Peacocke G. “Paratyphoid fever”. Trans Roy Acad Med Ir. 1911;29(1):55-63.

  8. Booth EB. “Paratyphoid fever”. Dub J Med Sci. 1905; 119(2);114-8.

  9. Prichard R. “Selected items from the history of pathology. Frank Burr Mallory”. Am J Pathol. 1979;95(2):422.

  10. Silva-Herzog E, Detweiler CS. “Intracellular microbes and haemophagocytosis”. Cell Microbiol. 2008;10(11):2151- 8. Epub 2008 Jun 23.

  11. Nix RN, Altschuler SE, Henson PM, Detweiler CS. Hemophagocytic macrophages harbor Salmonella enterica during persistent infection. PLoS Pathog. 2007;3(12):e193

  12. Martínez Durán C. “Histopatología de las lesiones del tifo exantemático- primera investigación hecha en Guatemala”. Disponible en: http://hist.library.paho.org/Spanish/ BOL/v23n9p791.pdf

  13. Hernández LD, Pypaert M, Flavell RA, Galán JE. “A Salmonella protein causes macrophage cell death by inducing autophagy”. J Cell Biol. 2003;163(5):1123-31.

  14. Nguyen QC, Everest P, Tran TK, et al. “A clinical, microbiological, and pathological study of intestinal perforation associated with typhoid fever”. Clin Infect Dis. 2004; 39(1):61-7. Epub 2004 Jun 14.

  15. Saxena V, Basu S, Sharma CL. “Perforation of the gall bladder following typhoid fever-induced ileal perforation”. Hong Kong Med J. 2007;13(6):475-7.

  16. Khan M, Coovadia Y, Sturm AW. “Typhoid fever complicated by acute renal failure and hepatitis: case reports and review”. Am J Gastroenterol. 1998;93(6):1001-3.

  17. Mert A, Tabak F, Ozaras R, et.al. “Typhoid fever as a rare cause of hepatic, splenic, and bone marrow granulomas”. Intern Med. 2004;43(5):436-9.

  18. Huang GC, Chang CM, Ko WC. “Typhoid fever complicated by multiple organ involvement: report of two cases”. J Infect. 2005;51(2):E57-60.

  19. Thapa R, Mukherjee K, Chakrabartty S. “Splenic abscess as a complication of enteric fever”. Indian Pediatr. 2007; 44(6):438-40.

  20. Pancharoen C, Wongsawat J, Phancharoen S, et.al. “Typhoid glomerulonephritis in a child: a rare complication of typhoid fever”. Southeast Asian J Trop Med Public Health. 2001; 32(4):869-71.

  21. Kadappu KK, Rao PV, Srinivas N, Shastry BA. “Pancreatitis in enteric fever”. Indian J Gastroenterol. 2002; 21(1):32-3.

  22. Rombolà F, Bertuccio SN. “Typhoid fever and acute pancreatitis: two cases”. Infez Med. 2007;15(1):63-5.

  23. Yacaman Handal R, Flores Nava G, Escobedo Chávez E, Pérez Bernabé MM. “Pancreatitis aguda secundaria a fiebre tifoidea en un preescolar”. Rev Gastroenterol Mex. 2000; 65(1):30-3.

  24. Kim H, Jeoung JY, Ham SY, Kim SR. “Non-typhoid Salmonella meningitis complicated by a infarction of basal ganglia”. J Korean Med Sci. 1999;14(3):342-4.

  25. Ramachandran S, Wickremesinghe HR, Perera MV. “Acute disseminated encephalomyelitis in typhoid fever”. Br Med J. 1975;1(5956):494-5.

  26. Shin BM, Paik IK, Cho HI. “Bone marrow pathology of culture proven typhoid fever”. J Korean Med Sci. 1994; 9(1):57-63.

  27. Rafatellu M, Wilson RP, Winter SE, Baümler AJ. “Clinical pathogenesis of typhoid fever”. J Infect Developing Countries 2008;2(4):260-6.

  28. Heat W. “Monster Soup Commonly Called Thames Water”. 1828. Disponible en: http://www.scienceandsociety.co.uk/ results.asp?image=10315337&screenwidth=1366




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