medigraphic.com

2010, Number 1

<< Back Next >>

Rev Educ Bioquimica 2010; 29 (1)

Los receptores nicotínicos de acetilcolina y las α-conotoxinas

López VE

Language: Spanish
References: 14
Page: 8-12
PDF size: 204.92 Kb.


ABSTRACT

Cone snails (Conus) are marine gastropods that use venom as the major weapon for prey capture. Their venoms are composed by a vast number of specialized toxins that selectively target particular receptors and ion channels; among others, the nicotinic acetylcholine receptors. Studies of conotoxins (α-conotoxins) have been useful for understanding the physiological role of these receptors.


REFERENCES

  1. Bernard C (1857) Legon sur les effects des substances toxiques etmédicamenteuses. París, J B Bailliere et Fils, p 488.

  2. Langley JN (1905) On the contraction of muscle, chiefly in relation to the presence of "receptive substances". Part IV. The effect of curari and of some other substances on the nicotina response of the sartorius and gastrocnemius muscles of the frog. J Physiol 33:73-108.

  3. Changeux JP, Devillers-Thiéry A, Chemouilli P (1984) Acetylcholine receptor: an allosteric protein. Science 225:1335-1345.

  4. Nirthanan S, GweeMC (2004) Three-finger alpha-neurotoxins and the nicotinic acetylcholine receptor, forty years on. J Pharmacol Sci 94:1-17.

  5. López-Vera E,Aguilar RamírezMB, Heimer de la Cotera E (2006) Toxinas de caracoles marinos del Género Conus. Ciencia 57:47-51.

  6. Teichert RW, Rivier J, Torres J, Dykert J, Miller C, Olivera BM(2005)Auniquely selective inhibitor of the mammalian fetal neuromuscular nicotinic acetylcholine receptor. J Neurosci 25:732-6.

  7. Jacobsen R, Yoshikami D, Ellison M, Martinez J, Gray W R, Cartier GE, Shon KJ, Groebe DR, Abramson SN, Olivera BM,McIntosh JM (1997) Differential targeting of nicotinic acetylcholine receptors by novel alphaAconotoxins. J Biol Chem 272:22531-22537.

  8. McIntosh JM, Santos AD, Olivera BM (1999) Conus peptides targeted to specific nicotinic acetylcholine receptor subtypes. Annu Rev Biochem 68:59-88.

  9. Shon KJ, Grilley M, Jacobsen R, Cartier GE, Hopkins C, GrayWR,WatkinsM, Hillyard DR, Rivier J, Torres J, Yoshikami D, Olivera BM (1997)Anoncompetitive peptide inhibitor of the nicotinic acetylcholine receptor from Conus purpurascens venom. Biochemistry 36:9581-9587.

  10. Ellison M, Gao F, Wang HL, Sine SM, McIntosh JM, Olivera BM(2004)Alpha-conotoxins ImI and ImII target distinct regions of the human alpha7 nicotinic acetylcholine receptor and distinguish human nicotinic receptor subtypes. Biochemistry 43:16019-16026.

  11. Ellison M, McIntosh JM, Olivera BM (2003) Alphaconotoxins ImI and ImII. Similar alpha 7 nicotinic receptor antagonists act at different sites. J Biol Chem 278:757-764.

  12. Ellison M, Haberlandt C, Gomez-Casati ME, Watkins M, Elgoyhen AB, McIntosh JM, Olivera BM (2006) Alpha-RgIA: a novel conotoxin that specifically and potently blocks the alpha9alpha10 nAChR. Biochemistry 45:1511-1517.

  13. Vincler M, Wittenauer S, Parker R, Ellison M, Olivera BM, McIntosh JM (2006) Molecular mechanism for analgesia involving specific antagonism of alpha9alpha10 nicotinic acetylcholine receptors. Proc Natl Acad Sci 103:17880-17884.

  14. Teichert RW, Rivier J, Torres J, Dykert J, Miller C, Olivera BM (2005)Auniquely selective inhibitor of the mammalian fetal neuromuscular nicotinic acetylcholine receptor. J Neurosci 25:732-736.




2020     |     www.medigraphic.com