Olivares RJA, Arellano PA

Language: Spanish
References: 16
Page: 9-18
PDF size: 365.83 Kb.

ABSTRACT

Insulin is a hormone released by pancreatic beta cells in response to elevated levels of nutrients in the blood, controlling critical energy functions such as glucose and lipid metabolism. When insulin binds to the insulin receptor (IR), the activated receptor triggers multiple signaling pathways that mediate the biological actions of insuline. Failure of target cells to respond to insulin presumably because of defects in the insulin signaling pathway, a state known as insulin-resistance, is a major attribute to the pathological manifestations associated with diabetes mellitus type 2 (DM2), one of the first causes of death in Mexico and worldwide. The objective of the present review is to unravel the molecular basis for insulin actions and the mechanisms involved in regulating its effects. Understanding these mechanisms will allow us to understand what are the causes associated with the development of insulin resistance and DM2.

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