Shiguetomi MJM, Urlich SK, Damgaard PH

Language: Spanish
References: 13
Page: 31-34
PDF size: 253.79 Kb.

ABSTRACT

Background: Phosphorus is the second most found mineral in the human body. It is found principally in the bone and interacts with calcium on the mineralization and morphological changes of the bone. Densitometry studies have traditionally related to the amount of calcium inside the bone. However, there are studies that suggest that there is a close interaction between calcium and phosphorus over the bone metabolism. The objective of this study is to describe the effect of a low, an adequate and a high-content phosphorus diet on the mineralization and bone development establishing a method that could be reproduced to study other mineral compounds on an animal model. Method: 18 female Duroc-race pigs, still growing, and with an initial weight of 40 kg were divided in three groups: Los phosphorus diet (4.1 g/kg of dry fed), normal diet (6.2 g/kg of dry fed), and high phosphorus diet (8.8 g/kg of dry fed). When the normal-fed group reached 105 kg of weight, the animals were physically examined and euthanized. Then, the left femur was obtained and analyzed using qCT on 3 regions (proximal epiphysis, distal epiphysis and a middle point between them). A complete statistical analysis was done to all data. Results: Bone mineralization (density) is affected by the phosphorus content in the diet. A low content of phosphorus in the food-intake significantly reduces the density and bone volume (p ‹ 0.01) in the femur while a high content of phosphorus causes no differences on these characteristics when compared to the group fed with normal intake of phosphorus. A deficient intake of this mineral decreases growth, while an excessive intake of it does not represent any growth-changes. Conclusion: A low-content of phosphorus in the diet during growth negatively affects the phosphorus storage, mineralization, development and growth. Also, a high intake of this mineral increases its retention but has no influence over mineralization (density) or bone morphology.

REFERENCES

1. Yu SLA. Disorders of magnesium and phosphorous. In: Goldman L, Schafer AI, eds. Cecil medicine. 24th ed. Philadelphia, PA. Saunders Elsevier 2011: chap 121

2. Abrams S A, Atkinson SA. Calcium, magnesium, phosphorus and vitamin D fortification of complementary foods. Journal of Nutrition 2003; 133: 2994-2999.

3. Shapiro R, Heaney RP. Co-dependence of calcium and phosphorus for growth and bone development under conditions of varying deficiency. Bone 2003; 32(5): 532-540.

4. Wray CJ, Mayes T, Khoury J, Warden G, Gottchlich M. Metabolic effects of vitamin D on serum calcium, magnesium, and phosphorus in pediatric burn patients. Journal of Burn Care & Rehabilitation 2002; 23(6): 416-423.

5. Heaney RP. Phosphorus nutrition and the treatment of osteoporosis. Mayo Clin Proc 2004; 79: 91-97.

6. Heaney RP, Nordin BEC. Calcium effects on phosphorus absorption: Implications for the prevention and co-therapy of osteoporosis. Journal of the American College of Nutrition 2002; 21(3): 239-244.

7. Roughead ZK, Johnson LK, Lykken GI, Hunt JR. Controlled high meat diets do not affect calcium retention or indices of bone status in healthy postmenopausal women. Journal of Nutrition 2003: 133: 1020-1026.

8. Rozen GS, Rennert G, Rennert HS, Diab G, Daud D, Ish-Shalom S. Calcium intake and bone mass development among Israeli adolescent girls. Journal of the American College of Nutrition 2001; 20(3): 219-224.

9. Charmetant C, Phaner V, Condemine A, Calmels P. Diagnosis and treatment of osteoporosis in spinal cord injury patients: A literature review. Ann Phys Rehabil Med 2010; 53(10): 655-668.

10. Briggs, HM. International pig breed encyclopedia. Elanco Animal Health, 1983.

11. Chapurlat R. Indications of bone densitometry. Rev Prat 2012; 62(2): 202-203.

12. Hayashida K, Takeda Y, Katsuda T, Yamamoto K, Suesada Y, Shibata M, Azuma MK. Measurements and evaluation of proximal femoral bone mineral density with dual energy X-rayabsorptiometry. Acta Med Okayama 2012; 66(1): 17-21.

13. Link TM. Osteoporosis imaging: state of the art and advanced imaging. Radiology 2012; 263(1): 3-17.