Shiguetomi MJM, Stødkilde-Jorgensen H, Rahbek O, Møller-Madsen B

Language: Spanish
References: 10
Page: 35-39
PDF size: 635.50 Kb.

ABSTRACT

Background: Experimental model to describe and measure the blood flow and cartilage metabolism from the growth plate of the tibiae in a porcine animal model using specialized Magnetic Resonance sequences adapted to bone analysis. Method: Four ex vivo normal tibiae and six in vivo from skeletally-immature growing animals were studied using ordinary T1 and T2 MRI. The results were compared and then analyzed using specialized sequences of Apparent Diffusion Coefficient and Water Content. Results: Water Content and DTI images can measure the amount and freedom of movement of the water molecules inside a tissue. This measurements, after being analyzed, can be interpreted as blood flow and cellular metabolism. Using a specialized software these parameters can be quantified using an arbitrary color scale that allows to compare the blood flow and metabolic activity between specimens. Conclusion: Information obtained from these MR sequences can provide additional information about the structure and growth plate behavior compared to the traditional study methods. This may be a new application for specialized MR sequences.

REFERENCES

1. Diccionario de la Real Academia Española. URL: www.rae.es (2012)

2. González JE, Lee M, Barniquinero JF, Valente M, Roch-Lefèvre S, García O. Quantitative image analysis of gamma-H2AX foci induced by ionizing radiation applying open source programs. Anal Quant Cytol Histol 2012; 34(2): 66-71.

3. Li KC, Henkelman RM, Poon PY, Rubenstein J. MR imaging of the normal knee. J Comput Assist Tomogr 1984; 8(6): 1147-1154.

4. Bézière N, Decroos C, Mkhitaryan K, Kish E, Richard F, Bigot-Marchand S, Durand S, Cloppet F, Chauvet C, Corvol MT, Rannou F, Xu-Li Y, Mansuy D, Peyrot F, Frapart YM. First combined in vivo X-ray tomography and high-resolution molecular electron paramagnetic resonance (EPR) imaging of the mouse knee joint taking into account the disappearance kinetics of the EPR probe. Mol Imaging 2012; 11(3): 220-228.

5. Peterfy CG, Dicarlo JC, Olech E, Bagnard MA, Gabriele A, Gaylis N. Evaluating joint-space narrowing and cartilage loss in rheumatoid arthritis by using MRI. Arthritis Res Ther 2012; 14(3): R131.

6. Patsch JM, Burghardt AJ, Kazakia G, Majumdar S. Noninvasive imaging of bone microarchitecture. Ann N Y Acad Sci 2011; 1240: 77-87. DOI: 10.1111/j.1749-6632.2011.06282.x

7. Gerriets T, Walberer M, Ritschel N, Tschernatsch M, Mueller C, Bachmann G, Schoenburg M, Kaps M, Nedelmann M. Edema formation in the hyperacute phase of ischemic stroke. Laboratory investigation. J Neurosurg 2009; 111(5): 1036-1042.

8. Hannoun S, Durand-Dubief F, Confavreux C, Ibarrola D, Streichenberger N, Cotton F, Guttmann CR, Sappey-Marinier D. Diffusion tensor-MRI evidence for extra-axonal neuronal degeneration in caudate and thalamic nuclei of patients with multiple sclerosis. AJNR Am J Neuroradiol 2012.

9. Accadbled F, Foster BK. Management of growth plate injuries. In: Benson M, Fixsen J, Macnicol M, Pasch K. Children’s orthopaedics and fractures. 3rd ed. Springer; 2010. Chaper 41; p. 687-699.

10. Lu A, Daniel BL, Kaye E, Pauly KB. MRI of frozen tissue demonstrates a phase shift. Mag Res Med 2011; 66(6): 1582-1589. DOI: 10.1002/mrm.22953