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2002, Number 1

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Rev Med Hosp Gen Mex 2002; 65 (1)

Respiratory scleroma. Report of two cases with fatal evolution

Escobar AJ, Castro GL, Soriano RJ, Guevara LGB, Franco LS, Olvera RJE

Language: Spanish
References: 10
Page: 36-40
PDF size: 346.31 Kb.


ABSTRACT

Scleroma is a chronic granulomatous disease of the mucosa of the nasal pasages and may involve the pharynx, larynx, trachea and bronchi by local extension. Its causative organism is Klebsiella rhinoscleromatis, a gram negative diplobacillus. Its histological hallmark consist of chronic plasma cell infiltrate, Mikulicz cells and Gram negative bacilli. We present the histopathological hallmark of scleroma with extension of larynx and bronchi in two cases of fatal evolution. It is infrequent that this lesions have a fatal evolution. The most severe and sometimes fatal findings were tracheal obstruction wich consisted of granulomatous, nodular masses and ulcer extending down the trachea and into the bronchi. Two post mortem cases are presented in patients that had been treated with antibiotics and in whom the lesion extended and caused obstruction of the airways and caused a fatal clinical course as a direct cause of these complications.


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