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ISSN 0185-6014 (Print)
Órgano oficial de difusión de la Federación Mexicana de Patología Clínica, AC y de la Asociación Latinoamericana de Patología Clínica/Medicina de Laboratorio

2004, Number 1

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Rev Mex Patol Clin Med Lab 2004; 51 (1)

Clinical laboratory evaluation of the employment cystatin C as substitute test of the clearance creatinine

Herrera-Pérez E, Vigueras-Rueda E

Language: Spanish
References: 11
Page: 49-57
PDF size: 78.42 Kb.


ABSTRACT

Before introducing a new analytical method in the Clinical Laboratory, it should be verified its clinical usefulness already informed in literature. It has been described the serum Cystatin C measurement as means to evaluate glomerular filtration rate. In the clinical laboratory this evaluation is accomplished by creatinine clearance in 24 h urine sample measurement. In this work were compared results of measured creatinine clearance (urine-24 h) with obtained for serum Cys C from 100 patients (50 males; 50 females), ages 7-70 years old, referred to the lab. As comparison baseline for Cys C performance, the results obtained from calculated creatinine clearance (Cockcroft-Gault) were used. It was found that Cys C concentration correlated with measured creatinine clearance, being this results comparable statistically with calculated clearance creatinine. By this way, we concluded that Cys C may substitute, in the clinical laboratory, creatinine clearance measurement.


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