2011, Number 2
Rev Med MD 2011; 2.3 (2)
Sainz-Escarrega VH, Montes de Oca-Morales MG
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ABSTRACT26-years-old male patient diagnosed with infection by Human Immunodeficiency Virus (HIV) onset with pulmonary tuberculosis (TB). In the appointments of control, the patient shows violaceous oral lesions compatible with Kaposi's sarcoma (KS). During the evolution of the patient, the TB disseminates to the pericardium and a treatment with corticosteroids (prednisone) was started. Subsequently, the patient presented a variety of breathing symptoms exacerbation and bilateral interstitial infiltrates, suspecting of dissemination of KS to the lung. The diagnostic is confirmed through a pulmonary biopsy and chemotherapeutic with paclitaxel is initiated. The Kaposi's sarcoma associated with HIV is a multifocal disorder angioproliferative that primarily affects the mucocutaneous tissue with invasion to many organs. Despite the introduction of the highly active antiretroviral treatment, the disease develops in approximately 15% of the patients infected with HIV. The pathogenesis is complex and involves the interaction between herpes virus type 8 (HSV-8), HIV, inflammatory cytokines and angiogenic factors.