Castelán-Maldonado EE, Peña-Ruelas CI, Ignacio-Morales CV, Romero-Martínez SA, Sánchez-Arbea PC

Language: Spanish
References: 21
Page: 153-157
PDF size: 1129.52 Kb.

ABSTRACT

Introduction: Seminoma comprises approximately 50% of testicular germ cell tumors. Renal metastases are infrequent, and are usually recognized at necropsy.
Clinical case: A 24 years-old man with history of left radical orchiectomy due to classical seminoma (stage I), and adjuvant radiotherapy, showed elevated levels of beta-human chorionic gonadotropin and lactate dehydrogenase in the eleven month follow-up. Computed tomography showed a 9 × 8 cm lobulated, heterogeneous tumor in the left kidney. The histopathological and immunohistochemical assay demonstrated a classical metastatic seminoma.
Conclusion: The majority of renal tumors represent primary neoplasm; in patients with extra-renal tumors we must consider the possibility of a metastatic disease.

REFERENCES

1. Voinea F, Vameşu S, Deacu M, Aşchie M, Poinăreanu I. Classical testicular seminoma in young man. Rom J Morphol Embryol 2006;47(4):379-384.

2. Garrido-Sánchez GA, Rodríguez-Montes CE. Características histopatológicas del seminoma en el Hospital Central Militar. Estudio retrospectivo a 10 años. Rev Sanid Milit Mex 2007;61(4):220-226.

3. Gholam D, Fizazi K, Terrier-Lacombe MJ, Jan P, Culine S, Theodore C. Advanced seminoma-treatment results and prognostic factors for survival after first-line, cisplatin-based chemotherapy and for patients with recurrent disease: a single-institution experience in 145 patients. Cancer 2003;98(4):745-752.

4. Rosai J, Chan JKC, Arber DA, Brunning RD, Desmet VJ, Kleinschmidt-Demasters BK, et al. Male reproductive system–Testis. In: Rosai J, editor. Rosai and Ackerman’s Surgical Pathology. 10th ed. China: Mosby Elsevier, 2011 p. 1338-1346.

5. Özsu S, Erol MM, Öztuna F, Ersöz Ş, Kavgaci H, Aksoy HZ. Endobronchial Metastasis from Testicular Seminoma. Med Princ Pract 2008;17:493-495.

6. Sharma R, Sekhon MS, Lal P. Metachronous metastasis from testicular cancer masquerading as a renal calculus. Br J Urol 1998;82(6):922.

7. Hadley DA, Cannon GH, Bishoff JT. A solitary seminoma renal metastasis presenting as an incidental renal mass. Urology 2010;75(2):245-246.

8. Cheng L. Establishing a germ cell origin for metastatic tumors using OCT4 immunohistochemistry. Cancer 2004;101(9):2006-2010.

9. Sahni VA, Silverman SG. Biopsy of renal masses: when and why. Cancer Imaging 2009;9:44-55.

10. Sánchez-Ortiz RF, Madsen LT, Bermejo CE, Wen S, Shen Y, Swanson DA, et al. A renal mass in the setting of a nonrenal malignancy: When is a renal tumor biopsy appropriate? Cancer 2004;101(10):2195-2201.

11. Qiu S, Luna MA. Testicular seminoma metastasizing to the parotid gland: report of a case. Head & Neck 2005;27(10):923-926.

12. Fujikawa K, Matsui Y, Oka H, Fukuzawa S, Sasaki M, Takeuchi H. Prognosis of Primary Testicular Seminoma: A Report on 57 New Cases. Cancer Res 2000;60(8):2152-2154.

13. Daugaard G, Karas V, Sommer P. Inguinal metastases from testicular cancer. BJU Int 2006;97(4):724-726.

14. Lockett CJ, Nandwani GM, Stubington SR. Testicular seminoma-unusual histology and staging with sub epithelial spread of seminoma along the vas deferans. BMC Urol 2006;6(1):5 (Consultado 2012 Enero 4). Disponible en http://www.biomedcentral.com/content/pdf/1471-2490-6-5.pdf

15. Sato A, Ohigashi T, Oya M, Nakashima J, Marumo K, Murai M. Clinicopathological Features Predicting Nodal Metastasis of Testicular Seminoma: Results from 100 Cases in a Single Institute. Urol Int 2006;77(1):64-68.

16. Aherne NJ, Small CA, McVey GP, Fitzpatrick DA, Armstrong JG. Abnormal hCG levels in a patient with treated stage I seminoma: a diagnostic dilemma. World J Surg Oncol 2008;6:68. (Consultado 2012, Enero 4). Disponible en http://www.wjso.com/content/pdf/1477-7819-6-68.pdf

17. Israel GM, Bosniak MA. How I Do It: Evaluating Renal Masses. Radiology 2005;236(2):441-450.

18. Silverman SG, Gan YU, Mortele KJ, Tuncali K, Cibas ES. Renal Masses in the Adult Patient: The Role of Percutaneous Biopsy. Radiology 2006;240(1):6-22.

19. Bokemeyer C, Kollmannsberger C, Stenning S, Hartmann JT, Horwich A, Clemm C, et al. Metastatic seminoma treated with either single agent carboplatin or cisplatin-based combination chemotherapy: a pooled analysis of two randomised trials. Br J Cancer 2004;91(4):683-687.

20. Malavasi N, Ferrara L, Fiorani C, Saviola A, Longo G. Diagnostic delay in oncology: a case report of metastatic seminoma. Case Rep Oncol 2011;4(1):216-221.

21. Bosl GJ, Bajorin DF, Scheinfeld J, Motzer RJ, Chaganti RSK. Cancer of the testis. In: DeVita VT, Lawrence TS, Resenberg SA, editor. Cancer: Principles and Practice of Oncology. 8th ed. Philadelphia: Lippincott Williams and Wilkins, 2008 p. 1463-1485.