Pérez-Díaz I, Hiriart M, Olivares-Reyes JA, Robles-Díaz G

Language: Spanish
References: 17
Page: 55-60
PDF size: 57.21 Kb.

ABSTRACT

The actions of Angiotensin II (Ang II) are becoming more and more numerous, turning from being only a vasoactive peptide into a peptide able to regulate specific cellular functions, like cytokine secretion and cellular proliferation. In addition, local Ang II generating systems have been described in most mammalian's tissues. Until now it is recognized that seven transmembrane domain receptors AT₁ and AT₂ are responsible for mediating Ang II actions. However, there is evidence suggesting that some of the Ang II effects are carried out through its union to sites spread as much in the cytoplasm, as in the nuclear membrane and the transcriptionally active chromatin, which probably correspond to peptides structurally and pharmacologically different from typical membrane receptors AT₁ and AT₂, denominated "non AT₁ non AT₂" receptors. This review comments about of the structure, function and location of these receptors, key elements that may explain action mechanisms of Ang II, and their role in the regulation of the cell function.

REFERENCES

1. Dinh DT, Fauman AG, Johnston CI, Fabiani ME (2001) Angiotensin receptors: distribution, signalling and function. Clin Sci (Lond) 100:482-492.

2. Filipeanu CM, Brailoiu E, Kok JW, Henning RH, De Zeeuw D, Nelemans SA (2001). Intracellular angiotensin II elicits Ca2+ increases in A7r5 vascular smooth muscle cells. Eur J Pharmacol 420:9-18.

3. Danser AH (2003) Local renin-angiotensin systems: the unanswered questions. Int J Biochem Cell Biol 35:759-768.

4. Kaschina E, Unger T (2003). Angiotensin AT1/AT2 receptors: regulation, signalin and function. Blood Press 12:70-88.

5. Touyz RM, Schiffrin EL (2000) Signal Transduction mechanisms mediating the physiological and pathophysiological actions of angiotensin II in vascular smooth muscle cells. Pharmacol Rev 52:639-672.

6. Escobar E, Rodríguez-Reyna TS, Arrieta O, Sotelo J (2004) Angiotensin II, cell proliferation and angiogénesis regulator: biologic and therapeutic implications in cancer. Curr Vasc Pharmacol 2:1-15.

7. Thomas WG, Qian H (2003). Arresting angiotensin type 1 receptors. Trends Endocrinol Metab 14:130-136.

8. Thomas WG, Mendelsohn FA (2003) Angiotensin receptors: form and function and distribution. The International Journal of Biochemistry Cell Biology 35:774- 779.

9. Sugiura N, Hagiwara H, Hirose S (1992) Molecular cloning of porcine soluble angiotensin-binding Prot. J Biol Chem 267:18067-18072.

10. Tang SS, Rogg H, Schumacher R, Dzau VJ (1992) Characterization of nuclear angiotensin II binding sites in rat liver and comparision with plasma membrane receptors. Endocrinology 131:374-380.

11. Booz GW, Conrad KM, Hess AL, Singer HA, Baker KM (1992) Angiotensin-II-binding sites on hepatocyte nuclei. Endocrinology 130:3641-3649.

12. Erdmann B, Fuxe K, Ganten D (1996) Subcellular localization of angiotensin II immunoreactivity in the rat cerebellar cortex. Hypertension 28:818-824.

13. Eggena P, Zhu JH, Clegg K, Barrett JD (1993) Nuclear angiotensin receptors induce transcription of renin and angiotensinogen mRNA. Hypertension 22:496-501.

14. Brailoiu E, Filipeanu CM, Tica A, Toma CP, de Zeeuw D, Nelemans SA (1999) Contractile effects by intracellular angiotensin II via receptors with a distinct pharmacological profile in rat aorta. Br J Pharmacol 126:1133-1138.

15. Cook JL, Zhang Z, Re RE (2001) In vitro Evidence for an Intracelular site of angiotensin action. Cir Res 89:1138- 1146.

16. Conchon S, Monnot C, Teursch B, Corvol P, Clauser E (1994) Internalization of the rat AT1a and AT1b receptors: pharmacological and functional requirements. FEBS Lett. 349: 365-370.

17. Chen R, Mukhin YV, Garnovskaya MN, Thielen TE, Iijima Y, Huang C, Raymond JR, Ullian ME, Paul RV (2000) A functional angiotensin II receptor-GPF fusion protein. Am J Physiol Renal Physiol 279:F440-F448.