Pérez GOA, Montejo VN, Lázaro LJ, Castro CR, Estrada GA

Language: Spanish
References: 15
Page: 280-287
PDF size: 158.19 Kb.

ABSTRACT

Introduction: locoregional relapses after a breast cancer surgery is a big concern for the patient and a frustration to the performing surgeon.
Objectives: to perform a descriptive study of the tumor recurrence-associated variables in 949 surgical patients.
Methods: a database containing the data from operated patients in the period of 2005 through 2010 was made; the variables were identified and the univariate and multivariate analyses allowed determining the probable statistical association.
Results: it was observed that the incidence of locoregional recurrence was 4.4 %. The most common previous surgery was modified radical mastectomy in 52.4 % and 26.2 % of cases with axillary ganglionic metastasis at that time. The most frequent histological type was highly malignant infiltrating bile duct carcinoma. The vascular and lymphatic infiltration occurred in 42.8 % of patients. The most used treatment was removal of recurrence plus radiotherapy. The multivariate analysis was associated only to ganglionic metastasis with the reappearance of disease.
Conclusions: axillary ganglionic metastasis is still a factor indicating bad prognosis in the long follow-up of a patient.

REFERENCES

1. Veronesi U, Luini A, Del Vecchio M. Radiotherapy after breast-preserving surgery in women with localized cancer of the breast. The New England Journal of Medicine. 1993;328(22):1587-91.

2. Borner M, Bacchi M. First isolated locoregional recurrence following mastectomy for breast cancer: results of a phase III multicenter study comparing systemic treatment with observation after excision and radiation. Journal of Clinical Oncology. 1994;12:2071-7.

3. Fisher B, Anderson S, Redmond CK. Reanalysis and results after 12 years of follow-up in a randomized clinical trial comparing total mastectomy with lumpectomy with or without irradiation in the treatment of breast cancer. The New England Journal of Medicine. 1995;333:1456-61.

4. Buchanan CL, Dorn PL, Fey J, Giron G, Naick A, Mendez J, et al. Locoregional recurrence after mastectomy. J Am Coll Surg. 2006;203:469-74.

5. Sarasqueta C, Martínez-Camblor P, Mendiola A, Martínez-Pueyo I, Michelena M, Basterretxea M, et al. Supervivencia relativa en cáncer de mama después de la primera recidiva y factores pronóstico asociados. Med Clin. 2009;1:1-7.

6. Bergamo L, Bolívar E. Recaídas locales posterior a tratamiento radical del cáncer de mama. Rev Venez Oncol. 2010;22(3):201-4.

7. Schmoor C, Sauerbrei W. Role of Isolated Locoregional Recurrence of Breast Cancer: Results of Four Prospective Studies. Journal of Clinical Oncology. 2000;April 18(8)1696-708.

8. Waljee J, Newman L. Tratamiento neoadyuvante y quirúrgico del cáncer de mamas. Surg Clin N Am. 2007(87):399-415.

9. Sheik F, Pockaj B. Márgenes positivos después de terapia conservadora del cáncer de mama. Am J Surg. 2011;200(3):281-5.

10. Sabel M. Essential of Breast Surgery. 1st. ed. Madrid: Mosby Elselvier; 2009.

11. Borgen P, Hill A. Breast Diseases. Ed. Landes Bioscience; 2000.

12. Veronesi U, Galimberti V. Prognostic significance of number and level of axillary nodal metastasis in breast cancer. Breast. 1993;2:224-8.

13. Harris J: Diseases of the Breast, 2nd ed. Lippincott W&W. Management of Recurrent Breast Cancer; 2010.

14. Domínguez MA, Marcos M, Meiriño R. Factores predictivos y pronósticos en el cáncer de mama temprano. Anales Sis San Navarra. 2001;24:99-110.

15. Sneed G L, Duncan LD. Quantifying the Extent of Invasive Carcinoma and Margin Status in Partial Mastectomy Cases Having a Gross Lesion. American Journal of Clinical Pathology. 2011;136(5):747-53.