medigraphic.com
ISSN 1561-3054 (Electronic)

2013, Number 1

<< Back Next >>

Rev Cubana Med Trop 2013; 65 (1)

Mycobacterium avium intracellulare complex pulmonary disease species and therapeutic match

Pérez CH, Chacón ZY, García SE, Rodríguez AC, Valdés DS, Samper NJA

Language: Spanish
References: 14
Page: 57-65
PDF size: 151.33 Kb.


ABSTRACT

Introduction: the global concern about diseases caused by environmental mycobacteria is growing since their diagnosis and treatment are difficult.
Objectives: to determine the behavior of Mycobacterium avium intracellulare complex pulmonary disease, and the therapeutic match with the treatment given at Benéfico Jurídico Pneumological Hospital, during the 2000-2010 period.
Methods: a retrospective descriptive study of 55 patients diagnosed with the disease, who met the previously defined inclusion/exclusion criteria. The diagnostic registration trend was based on the linear correlation coefficient; the qualitative quantitative discrete variables used frequency distributions with percentage calculations and their respective 95% confidence intervals (CI).
Results: a decreasing trend in the diagnosis of pulmonary disease from Mycobacterium avium-intracellular complex species; 47.3 % of the studied patients aged 50 to 69 years. Most of the group had no occupation with epidemiological risk, and the pulmonary comorbidity was detected in 97.9 % of patients, mainly pulmonary tuberculosis. A mismatch between the received therapy and the recommended treatment by the American Thoracic Society (ATS) was proved in 100% of patients.
Conclusion: the introduction of a therapeutic program adapted to the internationally accepted standards of treatment is a must for the care of this group of patients in Benefico Juridico Hospital.


REFERENCES

  1. Caminero Luna JA. Guía de la Tuberculosis para médicos especialistas. Unión Internacional Contra la Tuberculosis y Enfermedades Respiratorias. París, Francia: Edit. 68 boulevard Saint Michel, 75006; 2003. p. 370-87.

  2. Ruiz Manzano J, Manterola JM, Ausina V, Sauret J. Nomenclatura y clasificación de las micobacterias. Arch Bronconeumol. 1998;34:154-7.

  3. Akasami TR. Mycobacterium avium complex pulmonary disease in patients wiht pre-existin lung disease. Clin Chest Med. 2002;23(3):643-53.

  4. Griffith DE, Aksamit T, Brown-Elliot BA, Catanzaro A, Dally Ch, Gordón F, et al. American Thoracic Society Documents. Diagnosis, treatment, and prevention of nontuberculous mycobacterial disease. Am J Respir Crit Care Med. 2007;175(4):367-416.

  5. Won-Jung K, Jung K, Kyeongman JK, Tae SK, Kyung SL, Young KP, et al. Clinical significance of nontuberculous micobacteria isolated from respiratory specimens in Korea. Chest. 2006;129(2):341-8.

  6. Field S, Cowie R. Lung disease due to the more common non tuberculous Mycobacteria. Chest. 2006;129(6):1653-72.

  7. Toyohiro H, Koichi M, Yutaka I, Takeshi K, Seshino I, Shuji T, et al. Environmental risk factors for pulmonary Mycobacterium avium-intracellulare complex disease. Chest. 2011;140(3):723-9.

  8. Nogales MC, Chávez M, Umbría S. Infección pulmonar por el complejo mycobacterium avium-intracellulare en pacientes con enfermedad pulmonar de base: un cuadro a tener en cuenta. Neumosur. 2000;12(3):48-9.

  9. Khan Z, Miller A, Bachan M, Donath J. Mycobacterium avium complex (MAC) lung disease in two inner city community hospitals: recognition, prevalence, co-infection with Mycobacterium Tuberculosis (MTB) and pulmonary function (PF) improvements after treatment. Open Respir Med J. 2010;(4):76-81.

  10. Gutiérrez ME, Villar HE, Montoto M, Vicente A, Longo LM, Hoffman M. Micobacteriosis pulmonar en pacientes HIV negativos en la ciudad de Buenos Aires, años 2003-2004. Medicina (Buenos Aires) [revista en la Internet]. 2006 Abr [citado 2012 Jul 19]; 66(2):139-43. Disponible en: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0025-76802006000200009&lng=es

  11. Martínez-Moragón E, Menéndez R, Santos M, Lorente R, Marco V. Enfermedad pulmonar por micobacterias ambientales oportunistas en pacientes sin infección por el virus de la inmunodeficiencia humana. Factores de riesgo, clínica, diagnóstico y evolución. Arch Bronconeumol. 1996;32:170-5.

  12. Takayuki I. Evaluation of a rapid detection method of clarithromycin resistance genes in Mycobacterium avium complex isolates. J Antimicrob Chemother. 2011;66(4):722-9.

  13. Van Ingen J, van der Laan T, Dek R, Boeree M, van Soolingen D. In vitro drug susceptibility of 2275 clinical non-tuberculous Mycobacterium isolates of 49 species in The Netherlands. International J Antimicrob Ag. 2010;35(2):169-73.

  14. Su Sim Y, Yun Park H, Kyeongman J, Gee YS, Kwon OJ, Won-Jung K. Standardized combination antibiotic treatment of Mycobacterium avium complex lung disease. Yonsei Univ Med. 2010;51(6):888-94.




2020     |     www.medigraphic.com