2013, Number 1
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Rev Mex Traspl 2013; 2 (1)
National survey of cytomegalovirus prophylaxis in organ transplantation
Manríquez-Reyes M, Martínez-Mier G, Ávila-Pardo SF, Méndez-López MT, Hernández-Jiménez JD, Hernández-Navarrete LS
Language: Spanish
References: 11
Page: 10-14
PDF size: 70.56 Kb.
ABSTRACT
Introduction: Cytomegalovirus is a herpes virus which causes infections in 30-80% of patients with a transplant organ. There are categories of risk in patients undergoing transplantation in relation to cytomegalovirus. Two strategies are used to prevent cytomegalovirus: universal prophylaxis and preemptive therapy. The aim of this study was to determine through a survey, the opinion of cytomegalovirus prophylaxis in the transplant community in our country.
Methods: Survey applied during the XVI Congress of the National Society of Transplantation (26-29 September 2012) to health professionals in transplantation and members of Mexican Society of Transplantation.
Results: We collected 83 surveys. The average age of respondents was 41 years, 54% were men. 42% percent of respondents have a surgical specialty related to transplantation and 31% a clinical specialty. The largest number came from the Distrito Federal (21.7%) with presence of 19 Mexican states. 66.3% had experience with the disease and 59% have a manual of procedures for it. The transplant more likely to suffer from cytomegalovirus was deceased donor transplants (63.9%) and the high-risk group (D+/R-) is the most frequently in their centers. The universal prophylaxis is more common than preemptive therapy and the preferred scheme is 100 days of valganciclovir (37.3%).
Conclusions: Exercises like this survey reveal important information nationally about the infection/cytomegalovirus disease. Prophylaxis schemes should be reviewed according to current international consensus (200 days).
REFERENCES
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Kotton CN, Kumar D, Caliendo AM et al. Transplantation Society International CMV Consensus Group. International Consensus Guidelines on the Management of cytomegalovirus in solid organ transplantation. Transplantation 2010; 89: 779-95.
Paya C, Humar A, Dominguez E et al. Efficacy and safety of valganciclovir versus oral ganciclovir for prevention of cytomegalovirus disease in solid organ transplant recipients. Am J Transplant 2004; 4: 611-20.
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Hernández-Jiménez JD, Hernández-Navarrete LS, Rodríguez-Fernández et al. Experiencia a largo plazo del programa de trasplante renal del Hospital Regional de Veracruz. Rev Mex Tras 2012; 1: 15-21.
http://www.cenatra.salud.gob.mx/descargas/contenido/trasplante/reporte_anual_2011.pdf